Anti-UQCRFS1 Products

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For Research Use Only. Not For Clinical Use.

Our experts in mitochondrial biology have you covered with premium anti-UQCRFS1 recombinant antibodies. UQCRFS1 is the iron-sulfur subunit of Complex III that encodes the enzyme responsible for transferring electrons directly to Cytochrome c. We provide high-quality anti-UQCRFS1 rAbs that are essential for studying its catalytic function in the electron transport chain and its contribution to ROS production.

UQCRFS1: The Iron-Sulfur Subunit of Complex III

Ubiquinol-Cytochrome c Reductase Iron-Sulfur Subunit 1 (UQCRFS1) is the catalytically important subunit of Complex III (Core Protein 6) that is also known as the Rieske iron-sulfur protein. It has a 2Fe-2S cluster and is the mobile carrier subunit that directly shuttles electrons from ubiquinol to cytochrome c. The reduction of cytochrome c is a critical step in the Q-cycle which is the central mechanism that couples the redox reactions of Complex III to proton pumping. Mitochondrial respiration is completely abolished if there are mutations or defects in UQCRFS1, which lead to energy failure and excess production of the toxic superoxide radical.

Alternative Names

Ubiquinol-Cytochrome C Reductase, Rieske Iron-Sulfur Polypeptide 1; Cytochrome B-C1 Complex Subunit 5; Ubiquinol-Cytochrome C Reductase Iron-Sulfur Subunit; Rieske Iron-Sulfur Protein; Rieske Protein UQCRFS1; Complex III Subunit 5; EC 1.10.2.2;

Background

Cytochrome b-c1 complex subunit Rieske, mitochondrial: Component of the mitochondrial ubiquinol-cytochrome c reductase complex dimer (complex III dimer), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. Incorporation of UQCRFS1 is the penultimate step in complex III assembly (By similarity).

Anti-UQCRFS1 rAb Products

Creative Biolabs' anti-UQCRFS1 recombinant antibodies have been engineered to be highly specific and to give you the best possible performance. Each lot is strictly validated for specific detection of the UQCRFS1 protein in mitochondrial fractions. We have also optimized our rAbs for use in Western Blot to check its expression and for IHC, to give you the dependability and specificity you need to do your metabolic research.

Table 1. Featured anti-UQCRFS1 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs has a reputation for scientific excellence, and nothing is more important to us than making sure you have the absolute best. Our proprietary quality assurance system is in place to ensure the anti-UQCRFS1 recombinant antibodies we produce are all very pure, completely specific, and give consistent performance in our validated mitochondrial detection assays.

Fig.1 WB analysis of anti-UQCRFS1 antibody
(Cat# VS3-FY1525, Creative Biolabs).

Customer Reviews

rAb Production

We know the field of mitochondrial research is a specialized one, which is why at Creative Biolabs we use our proprietary, advanced production platforms. The anti-UQCRFS1 recombinant antibodies are expressed in an optimized system that is guaranteed to make antibodies that specifically and actively recognize the native protein.

Featured Anti-UQCRFS1 Recombinant Antibody Production Platforms
Fig.2 Milligram-scale anti-UQCRFS1 recombinant antibody production.

Fig.3 Gram-scale anti-UQCRFS1 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to driving scientific discovery forward with high-quality antibody solutions, and we have the flexibility to provide you with a variety of antibody modalities in many customizable formats. Our anti-UQCRFS1 recombinant antibodies are just one example of how we will help power your research.

Fig.4 Full-length anti-UQCRFS1 recombinant antibody production and modalities.

Creative Biolabs' superior anti-UQCRFS1 recombinant antibodies will help you get down to the catalytic core of Complex III. The rigorous validation we do and the consistency in the performance of our antibodies provide you with the dependable specificity you need to do your research on this critical enzyme. Don't wait, contact one of our experts today.