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Anti-USP22 ProductsBackground

Anti-USP22 Products

Rabbit Anti-USP22 Recombinant Antibody (clone JU63-27) (MRO-1563-CN)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, FC, IP
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APC-A*02:01/Human Ubiquitin-specific protease 22 (YIYDKDMEII) MHC Tetramer (MHC-CN0353)
- Class: Class I
- Antigen: Ubiquitin-specific protease 22
- Antigen Species: Human
- Peptide: YIYDKDMEII
- Conjugate: APC
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PE-A*02:01/Human Ubiquitin-specific protease 22 (YIYDKDMEII) MHC Tetramer (MHC-CN0354)
- Class: Class I
- Antigen: Ubiquitin-specific protease 22
- Antigen Species: Human
- Peptide: YIYDKDMEII
- Conjugate: PE
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Mouse Anti-USP22 Recombinant Antibody (clone 1154CT13.1.3.1) (VS3-QX1223)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB
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Mouse Anti-USP22 Recombinant Antibody (clone 1G4) (VS3-XY1580)
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IP, IF
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Recombinant Rabbit Anti-USP22 Antibody (clone 18H6) (VS4-CJ151)
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, WB, IF, FC
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Recombinant Rabbit Anti-USP22 Antibody (clone R05-0D1) (VS3-FY1530)
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IP
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Anti-USP22 Immunohistochemistry Kit (VS-0325-XY2452)
- Species Reactivity: Human, Mouse
- Target: USP22
- Application: IHC
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Rabbit Anti-USP22 Recombinant Antibody (clone DS3805AB) (MOR-3805)
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: FC, ICC, IF, IP, WB
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For Research Use Only. Not For Clinical Use.

Background

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.

Protein class

Enzymes, Metabolic proteins

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ATXN7L3, ENY2 and USP22 form a subcomplex required for histone deubiquitination (PubMed:18206972, PubMed:27601583). Interacts directly with ATXN7L3; leading to its recruitment to the SAGA complex (PubMed:18206972). Interacts with ATXN7L3 and weakly with ATXN7L3B (PubMed:27601583).

Molecular function

Activator, Chromatin regulator, Hydrolase, Protease, Thiol protease

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