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VANGL2

Anti-VANGL2 Products

Human Anti-VANGL2 Recombinant Antibody; scFv Fragment (TAB-245CQ-S(P)) (TAB-245CQ-S(P))
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, WB, IP
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Human Anti-VANGL2 Recombinant Antibody; Fab Fragment (TAB-245CQ-F(E)) (TAB-245CQ-F(E))
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, WB, IP
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For Research Use Only. Not For Clinical Use.

The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate.

Protein class

Disease related genes

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Cone photoreceptor cells, Intestinal goblet cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (AF22, AN3-CA, NTERA-2, SH-SY5Y, SuSa)

Interaction

Homodimer and heterodimer with VANGL1. Interacts through its C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3 (By similarity). Interacts with PRICKLE3 (By similarity).

Molecular function

Developmental protein

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