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VSIG1

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For Research Use Only. Not For Clinical Use.


This gene encodes a member of the junctional adhesion molecule (JAM) family. The encoded protein contains multiple glycosylation sites at the N-terminal region, and multiple phosphorylation sites and glutamic acid/proline (EP) repeats at the C-terminal region. The gene is expressed in normal stomach and testis, as well as in gastric, esophageal and ovarian cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enriched (Gastric mucus-secreting cells)

Immune cell specificity

Immune cell enhanced (T-reg, naive CD4 T-cell)

Cell line specificity

Cell line enhanced (HBEC3-KT, HUVEC TERT2, PC-3, TIME)

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