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WFDC2

Anti-WFDC2 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation.
Protein class

Cancer-related genes

Predicted location

Intracellular, Secreted (different isoforms)

Single cell type specificity

Cell type enhanced (Club cells, Glandular and luminal cells, Basal respiratory cells, Urothelial cells, Endometrial ciliated cells, Respiratory ciliated cells, Collecting duct cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (A-431, CAPAN-2, EFO-21, HaCaT, RPTEC TERT1)

Interaction

Homotrimer; disulfide-linked.

Molecular function

Aspartic protease inhibitor, Protease inhibitor, Serine protease inhibitor, Thiol protease inhibitor

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