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WNK2
Loading...Anti-WNK2 Products
- Anti-WNK2 Immunohistochemistry Kit (VS-0525-XY7920)
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- Species Reactivity: Human
- Target: WNK2
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.
Protein class
Enzymes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cone photoreceptor cells, Excitatory neurons, Rod photoreceptor cells, Inhibitory neurons, Intestinal goblet cells, Astrocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (Daudi, Hep G2, SCLC-21H)
Interaction
Forms a complex with the phosphorylated form of STK39.
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
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