XK

Formats

Anti-XK Recombinant Antibody Products

Recombinant Anti-Human XK Antibody (MOB-1961z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, Neut, FuncS
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Recombinant Anti-Human XK Antibody Fab Fragment (MOB-1961z-F(E))
- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: WB, Neut, FuncS
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Recombinant Anti-Human XK Antibody scFv Fragment (MOB-1961z-S(P))
- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, IP, FuncS
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For Research Use Only. Not For Clinical Use.

This locus controls the synthesis of the Kell blood group 'precursor substance' (Kx). Mutations in this gene have been associated with McLeod syndrome, an X-linked, recessive disorder characterized by abnormalities in the neuromuscular and hematopoietic systems. The encoded protein has structural characteristics of prokaryotic and eukaryotic membrane transport proteins.

Protein class

Blood group antigen proteins, Disease related genes, Human disease related genes, Potential drug targets, Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Erythroid cells, Distal enterocytes, Proximal enterocytes, Gastric mucus-secreting cells, Undifferentiated cells)

Immune cell specificity

Group enriched (basophil, eosinophil)

Cell line specificity

Cell line enhanced (HEL, HL-60, K-562, NB-4, RPMI-8226)

Interaction

Heterodimer with Kell; disulfide-linked (PubMed:9593744). Interacts with VPS13A (PubMed:32845802, 31086825).

Molecular function

Blood group antigen

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