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XK
This locus controls the synthesis of the Kell blood group 'precursor substance' (Kx). Mutations in this gene have been associated with McLeod syndrome, an X-linked, recessive disorder characterized by abnormalities in the neuromuscular and hematopoietic systems. The encoded protein has structural characteristics of prokaryotic and eukaryotic membrane transport proteins.
Protein class
Blood group antigen proteins, Disease related genes, Human disease related genes, Potential drug targets, Transporters
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Erythroid cells, Distal enterocytes, Proximal enterocytes, Gastric mucus-secreting cells, Undifferentiated cells)
Immune cell specificity
Group enriched (basophil, eosinophil)
Cell line specificity
Cell line enhanced (HEL, HL-60, K-562, NB-4, RPMI-8226)
Interaction
Heterodimer with Kell; disulfide-linked (PubMed:9593744). Interacts with VPS13A (PubMed:32845802, 31086825).
Molecular function
Blood group antigen
More Types Infomation
- Recombinant Anti-Human XK Antibody (MOB-1961z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: WB, Neut, FuncS
- Recombinant Anti-Human XK Antibody scFv Fragment (MOB-1961z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, IP, FuncS
- Recombinant Anti-Human XK Antibody Fab Fragment (MOB-1961z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: WB, Neut, FuncS
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For Research Use Only. Not For Clinical Use.