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XRCC3
Anti-XRCC3 Recombinant Antibody Products
- Mouse Anti-XRCC3 Recombinant Antibody (clone 10F1/6) (FAMAB-1562CQ)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ICC, WB
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- Chicken Anti-XRCC3 (ab1) Polyclonal IgY (BRD-0635MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
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- Chicken Anti-XRCC3 (ab2) Polyclonal IgY (BRD-0636MZ)
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- Species Reactivity: Human
- Type: Chicken antibody
- Application: Indirect ELISA, WB
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified.
Protein class
Cancer-related genes, Disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cytotrophoblasts)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with RAD51C and RAD51. Part of the CX3 complex consisting of RAD51C and XRCC3; the complex has a ring-like structure arranged into a flat disc around a central channel; CX3 can interact with RAD51 in vitro. Forms a complex with FANCD2, BRCA2 and phosphorylated FANCG. Interacts with SWSAP1 and ZSWIM7; involved in homologous recombination repair. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3.
Molecular function
DNA-binding
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