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ZIC3
Anti-ZIC3 Recombinant Antibody Products
- Anti-ZIC3 Immunohistochemistry Kit (VS-0325-XY2534)
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- Species Reactivity: Human, Mouse, Rat
- Target: ZIC3
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs. [provided by RefSeq, Jul 2008]
Protein class
Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Muller glia cells, Microglial cells, Spermatogonia, Spermatocytes, Rod photoreceptor cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (AF22, NTERA-2, SuSa)
Interaction
Interacts (via the C2H2-type domains 3, 4 and 5) with MDFIC (via the C2H2-type domains 3, 4 and 5); the interaction reduces its transcriptional activity (By similarity). Interacts with KPNA1 and KPNA6. Interacts (via C2H2-type domains 3, 4 and 5) with GLI3; the interaction enhances its transcriptional activity.
Molecular function
Activator, Developmental protein, DNA-binding
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