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ZMYND8

Anti-ZMYND8 Products

Recombinant Mouse anti-Human ZMYND8 Monoclonal antibody (EML1439) (MOB-1632CT)
- Species Reactivity: Human
- Application: WB
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Anti-ZMYND8 Immunohistochemistry Kit (VS-0325-XY2538)
- Species Reactivity: Human, Mouse, Rat
- Target: ZMYND8
- Application: IHC
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Anti-Human ZMYND8 Immunohistochemistry Kit (VS-0525-XY8035)
- Species Reactivity: Human
- Target: ZMYND8
- Application: IHC
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For Research Use Only. Not For Clinical Use.

Background

The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Interacts in vitro with PRKCB1 (PubMed:11003709). Interacts with KDM5D and KDM1A (PubMed:27477906). Interacts with histone H3 (via N-terminus) that is both methylated at 'Lys-4' (H3K4me1) and acetylated at 'Lys-14' (H3K14ac), and with histone H3 (via N-terminus) unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-14' (H3K14ac) (PubMed:27477906). Interacts (via PHD-type Zinc finger, Bromo and PWWP domains) with DBN1 (via ADF-H domain); the interaction leads to sequestering of ZMYND8 in the cytoplasm (PubMed:28966017).

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