alpha toxin
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- Derivation: Mouse
- Species Reactivity: Staphylococcus aureus
- Type: Humanized IgG
- Application: FuncS
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- Recombinant Humanized Anti-alpha toxin scfv Fragment (MEDI4893) (HPAB-3190LY-S(P))
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- Derivation: Mouse
- Species Reactivity: Staphylococcus aureus
- Type: Humanized scfv
- Application: ELISA
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- Recombinant Humanized Anti-alpha toxin Fab Fragment (MEDI4893) (HPAB-3190LY-F(E))
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- Derivation: Mouse
- Species Reactivity: Staphylococcus aureus
- Type: Humanized Fab
- Application: ELISA
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- Human Anti-alpha toxin (clone MEDI4893) scFv-Fc Chimera (VS-0425-FY185)
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- Species Reactivity: S. aureus
- Type: Human IgG1, scFv-Fc
- Application: Neut, ELISA
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For Research Use Only. Not For Clinical Use.
Background
Alpha-toxin, also known as alpha-hemolysin (Hla), is the major cytotoxic agent released by bacterium Staphylococcus aureus and the first identified member of the pore forming beta-barrel toxin family.[1] This toxin consists mostly of beta-sheets (68%) with only about 10% alpha-helices. The hla gene on the S. aureus chromosome encodes the 293 residue protein monomer, which forms heptameric units on the cellular membrane to form a complete beta-barrel pore. This structure allows the toxin to perform its major function, development of pores in the cellular membrane, eventually causing cell death.
Alpha toxin is a pore-forming toxin. Monomers of the toxin secreted by S. aureus bind to the host cell membrane and oligomerize (typically into a heptamer) to form a transmembrane pore.