arnB
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Loading...- Mouse Anti-arnB Recombinant Antibody (clone 2506W1119) (VS-0625-FY1224)
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- Species Reactivity: Salmonella typhimurium (strain LT2/SGSC1412/700720)
- Type: Mouse IgG
- Application: ELISA
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For Research Use Only. Not For Clinical Use.
Background
This enzyme, often denoted ArnB or PmrE, is crucial for polymyxin resistance in bacteria. It catalyzes the transfer of an amino group from L-glutamate to UDP-4-keto-6-deoxy-L-mannose, forming UDP-4-amino-4-deoxy-L-arabinose. This sugar nucleotide is then incorporated into lipid A, modifying the bacterial outer membrane and reducing its affinity for cationic antimicrobial peptides like polymyxins.