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For Research Use Only. Not For Clinical Use.


Background

Dihydropteroate synthase (DHPS) is an enzyme involved in the biosynthesis of folate in bacteria, fungi, and plants. It catalyzes the condensation of p-aminobenzoate (PABA) with 6-hydroxymethyl-7,8-dihydropterin pyrophosphate to form dihydropteroate. DHPS is a major target for sulfonamide antibiotics due to its essentiality in microorganisms.
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