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gp41
Anti-gp41 Recombinant Antibody Products
- Mouse Anti-gp41 Antibody, mRNA (AGTO-L056R-mRNA)
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- Species Reactivity: HIV
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- anti-gp41 immunotoxin (IgG)-RTA (AGTO-L056R)
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- Species Reactivity: HIV
- Application: Cytotoxicity assay, Functional assay
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For Research Use Only. Not For Clinical Use.
gp41/120 is the major HIV protein associated with the HIV envelope. It functions as the viral antireceptor or attachment protein. gp41 (or TM) traverses the envelope, whereas gp120 is present on the outer surface and is noncovalently attached to gp41. The precursor of gp120/41 (gp160) is synthesized in the endoplasmic reticulum and is transported via the golgi body to the cell surface. Upon activation of the envelope glycoprotein (gp120/41) by cellular receptors, gp41 undergoes conformational changes that mediate fusion of the viral and cellular membranes.