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SNTB2

Anti-SNTB2 Products

PE-A*01:01/Human SNTB2 (YLDFGGPEG) MHC Tetramer (MHC-LC4443)
- Class: Class I
- Antigen: SNTB2
- Antigen Species: Human
- Peptide: YLDFGGPEG
- Conjugate: PE
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PE-A*02:01/Human SNTB2 (YLDFGGPEG) MHC Tetramer (MHC-LC4444)
- Class: Class I
- Antigen: SNTB2
- Antigen Species: Human
- Peptide: YLDFGGPEG
- Conjugate: PE
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For Research Use Only. Not For Clinical Use.

Background

Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes. [provided by RefSeq, Jul 2008]

Protein class

Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Muller glia cells, Excitatory neurons, Rod photoreceptor cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (SiHa)

Interaction

Monomer and homodimer (Probable). Interacts with the other members of the syntrophin family: SNTA1 and SNTB1; and with the sodium channel proteins SCN4A and SCN5A. Interacts with SAST, MAST205, microtubules and microtubule-associated proteins (By similarity). Interacts with the dystrophin protein DMD and related proteins DTNA and UTRN, and with the neuroregulin receptor ERBB4. Interacts with PTPRN when phosphorylated, protecting PTPRN from protein cleavage by CAPN1. Dephosphorylation upon insulin stimulation disrupts the interaction with PTPRN and results in the cleavage of PTPRN. Interacts with DTNB (By similarity).

Molecular function

Actin-binding, Calmodulin-binding

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