vegfaa

Vascular endothelial growth factor A (VEGF-A) is a protein that in humans is encoded by the VEGFA gene. Vascular endothelial growth factor (VEGF) is a kind of multifunctional cytokine specially used for vascular endothelial cells. Currently, there are six subtypes of VEGF, namely A, B, C, D, E and placental growth factor (PLGF). Under normal conditions, vegf-a is moderately expressed in alveolar epithelial cells, bronchial epithelial cells and bronchial gland cells. VEGF-A major in alveolar epithelial cells (especially type II lung epithelial cells), bronchial epithelial cells express, under normal circumstances, breathing epithelial cells of the high levels of VEGF-A not directly released into the blood, and in the acute phase of ALI/ARDS, alveolar epithelial cells and blood vessels inside the skin is damaged, ruined the alveolar air-blood barrier, respiratory epithelial cells within the VEGF-A released into the blood stream, VEGF-A combined with VEGF receptors on the surface of the vascular endothelial cells, increased vascular permeability. Vegf-a is currently found to have the strongest effect and the highest specificity in vascular permeability. It can significantly increase the permeability of capillary posterior veins and small veins, and its effect is 50,000 times that of histamine. Moreover, this effect cannot be blocked by antihistamines and platelet activation factor inhibitors.