ανβ8

In general, integrins are adhesion molecules and mediate the attachment of cells to extracellular matrix proteins. Integrin avp8 binds to the LAP of TGF-β and mediates the activation of TGF-βΙ and 3. Integrin v'PS-mediated activation of TGF-β is required for in vivo activation of TGF-β, thus αvβ8 is a gatekeeper of TGF-β function. Integrin cxvβS is expressed in normal epithelia, mesenchymal cells, and neuronal tissues. The integrin β8 has been associated with forkhead box P3 (Foxp3)-positive T cells and T-regulatory-specific epigenetic remodeling. FoxP3 is a transcription factor involved in the development of T-regulatory (Treg) cells. Human and mouse effector Treg cells express functional TGF-P-activating integrin ανβ8.