10-FnIII anti-ARVCF peptide (SFN-L002)

The tenth fibronectin type III domain (10Fn3) that bound ARVCF peptide was isolated from the library using Phage display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=4 nM) for ARVCF peptide as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.      

Scaffold Name
Core Structure
β-sandwich of 7 β-strands
Variable Regions
2–3 Loops
ARVCF peptide
Expression Host
BL21 (DE3) cells
Affinity Constant
4 Nm
ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study
Alternative Names
Fibronectin; 10-FnIII; ARVCF; ARVCF peptide

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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