10-FnIII scaffold protein anti-SARS N protein

CAT#: SFN-L020

The tenth fibronectin type III domain (10Fn3) that bound SARS N protein was isolated from the library using mRNA Display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=1.7 nM) for SARS N protein as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.

Specifications

  • Scaffold Name
  • 10-FnIII
  • Origin
  • Fibronectin
  • Core Structure
  • β-sandwich of 7 β-strands
  • Variable Regions
  • 2–3 Loops
  • Target
  • SARS N protein
  • Species Reactivity
  • SARS
  • Expression Host
  • E. coli
  • Affinity Constant
  • 1.7 nM
  • Applications
  • ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study

Target

  • Alternative Names
  • Fibronectin; 10-FnIII; sars9a; nucleocapsid protein; N protein; N
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