10-FnIII anti-N (SFN-L020)
The tenth fibronectin type III domain (10Fn3) that bound SARS N protein was isolated from the library using mRNA Display technology. The fibronectin type III domain (FN3) is a small autonomous folding unit which occurs in many animal proteins involving in ligand binding. The β-sandwich structure of FN3 closely resembles that of immunoglobulin domains. After affinity maturation, 10Fn3 variants were identified having affinities (KD=1.7 nM) for SARS N protein as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Specifications
- Scaffold Name
- 10-FnIII
- Origin
- Fibronectin
- Core Structure
- β-sandwich of 7 β-strands
- Variable Regions
- 2–3 Loops
- Target
- SARS N protein
- Species Reactivity
- SARS
- Expression Host
- E. coli
- Affinity Constant
- 1.7 nM
- Applications
- ELISA; immunohistochemistry; Microscopy; Flow Cytometer; Western Blotting; Functional Study
Target
- Alternative Names
- Fibronectin; 10-FnIII; sars9a; nucleocapsid protein; N protein; N
- Entrez Gene ID
- 1489678
- UniProt ID
- P59595
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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