Anti-FcrL5 (clone 13G9)-mc-vc-PABC-MMAE ADC
CAT#: ADC-056LZY
This ADC product is composed of an anti-FcrL5 antibody (clone 13G9 ) conjugated via mc-vc-PABC
linker to MMAE (13G9-mc-vc-PABC-MMAE). It has demonstrated a response in Multiple myeloma (MM) treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Group enriched (U-266/70, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000143297-FCRL5
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Specifications
- Antibody Overview
- Anti-FcRL5 Antibody,13G9 or10A8
- Clone
- 13G9
- Linker
- mc-VC-PABC (maleimidocaproyl-valine-citrulline-paminobenzyloxycarbonyl)
- Linker Class/Description
- Class: Enzymatically cleavable linker-Peptide linker
Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
- Drug
- MMAE (monomethyl auristatin E)
- Drug Class/Description
- Class: Auristatin
Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
- Alternative Names
- FCRL5; Fc receptor-like 5; CD307; FCRH5; IRTA2; BXMAS1; CD307e; PRO820; Fc receptor-like protein 5; fcR-like protein 5; fc receptor homolog 5; immune receptor translocation-associated protein 2; immunoglobulin superfamily receptor translocation associated 2 (IRTA2);
- Gene ID
- 83416
- UniProt ID
- Q96RD9
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Datasheet
MSDS
COA
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See other products for "Clone 13G9"
- CAT
- Product Name
See other products for "FCRL5"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0590CL-S(P) | Mouse Anti-FCRL5 Recombinant Antibody; scFv Fragment (TAB-0590CL-S(P)) | ELISA, FC, WB | Mouse scFv |
| TAB-0591CL-S(P) | Mouse Anti-FCRL5 Recombinant Antibody; scFv Fragment (TAB-0591CL-S(P)) | ELISA, FC, WB | Mouse scFv |
| TAB-0590CL-F(E) | Mouse Anti-FCRL5 Recombinant Antibody; Fab Fragment (TAB-0590CL-F(E)) | ELISA, FC, WB | Mouse Fab |
| TAB-0591CL-F(E) | Mouse Anti-FCRL5 Recombinant Antibody; Fab Fragment (TAB-0591CL-F(E)) | ELISA, FC, WB | Mouse Fab |
| TAB-0592CL-F(E) | Mouse Anti-FCRL5 Recombinant Antibody; Fab Fragment (TAB-0592CL-F(E)) | ELISA, FC, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-056CQ | Mouse Anti-FCRL5 Recombinant Antibody (MOB-056CQ) | ELISA, FC, FuncS | Mouse IgG1, κ |
| MOB-057CQ | Mouse Anti-FCRL5 Recombinant Antibody (clone 13G9) | ELISA, FC, FuncS | Mouse IgG1, κ |
| HPAB-1807LY | Human Anti-FCRL5 Recombinant Antibody (HPAB-1807LY) | ELISA, FC | Human IgG |
| HPAB-1808LY | Mouse Anti-FCRL5 Recombinant Antibody (HPAB-1808LY) | ELISA, FC | Mouse IgG |
| HPAB-1809LY | Mouse Anti-FCRL5 Recombinant Antibody (HPAB-1809LY) | ELISA, FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0180CQ-F(E) | Human Anti-FCRL5 Recombinant Antibody (clone 9D12); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0181CQ-F(E) | Human Anti-FCRL5 Recombinant Antibody (clone 8A1); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-AP650-YC-F(E) | Mouse Anti-FCRL5 Recombinant Antibody; Fab Fragment (HPAB-AP650-YC-F(E)) | FC, FuncS | Mouse Fab |
| HPAB-AP651-YC-F(E) | Human Anti-FCRL5 Recombinant Antibody; Fab Fragment (HPAB-AP651-YC-F(E)) | FC, FuncS | Human Fab |
| HPAB-AP652-YC-F(E) | Human Anti-FCRL5 Recombinant Antibody; Fab Fragment (HPAB-AP652-YC-F(E)) | FC, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0180CQ-S(P) | Human Anti-FCRL5 Recombinant Antibody (clone 9D12); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-0181CQ-S(P) | Human Anti-FCRL5 Recombinant Antibody (clone 8A1); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-1807LY-S(P) | Human Anti-FCRL5 Recombinant Antibody; scFv Fragment (HPAB-1807LY-S(P)) | ELISA, FC | Human scFv |
| HPAB-1808LY-S(P) | Mouse Anti-FCRL5 Recombinant Antibody; scFv Fragment (HPAB-1808LY-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-1809LY-S(P) | Mouse Anti-FCRL5 Recombinant Antibody; scFv Fragment (HPAB-1809LY-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC616 | Recombinant Anti-FCRL5 Vesicular Antibody, EV Displayed (VS-0425-YC616) | ELISA, FC, Cell-uptake |
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