Anti-FcRH5 (clone 13G9)-SMCC-DM1 ADC
CAT#: ADC-164CL
This ADC product is composed of an anti-FcRH5 antibody (clone 13G9) conjugated via SMCC linker to DM1(Mu-anti-FcRH5 (13G9)-mcc-dm1). It has demonstrated a response in treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Group enriched (U-266/70, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000143297-FCRL5
❮
❯
Specifications
- Antibody Overview
- Mu-Anti-FcRH5 (13G9)
- Clone
- 13G9
- Linker
- SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Linker Class/Description
- Class: Noncleavable linkers
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
- Drug
- DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
- Drug Class/Description
- Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.
Target
- Introduction
- This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
- Alternative Names
- FCRL5; Fc receptor-like 5; CD307; FCRH5; IRTA2; BXMAS1; CD307e; PRO820; Fc receptor-like protein 5; fcR-like protein 5; fc receptor homolog 5; immune receptor translocation-associated protein 2; immunoglobulin superfamily receptor translocation associated 2 (IRTA2);
- Gene ID
- 83416
- UniProt ID
- Q96RD9
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for ADC-164CL. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone 13G9"
- CAT
- Product Name
See other products for "FCRL5"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2390z-F(E) | Recombinant Anti-Human FCRL5 Antibody Fab Fragment | IF, FC, FuncS | Fab |
| HPAB-0016CQ-F(E) | Human Anti-FCRL5 Recombinant Antibody; Fab Fragment (HPAB-0016CQ-F(E)) | ELISA, WB, RIA | Human Fab |
| HPAB-0017CQ-F(E) | Human Anti-FCRL5 Recombinant Antibody; Fab Fragment (HPAB-0017CQ-F(E)) | ELISA, WB, RIA | Human Fab |
| HPAB-0018CQ-F(E) | Human Anti-FCRL5 Recombinant Antibody; Fab Fragment (HPAB-0018CQ-F(E)) | RIA, ELISA | Humanized Fab |
| HPAB-1807LY-F(E) | Human Anti-FCRL5 Recombinant Antibody; Fab Fragment (HPAB-1807LY-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0590CL-S(P) | Mouse Anti-FCRL5 Recombinant Antibody; scFv Fragment (TAB-0590CL-S(P)) | ELISA, FC, WB | Mouse scFv |
| TAB-0591CL-S(P) | Mouse Anti-FCRL5 Recombinant Antibody; scFv Fragment (TAB-0591CL-S(P)) | ELISA, FC, WB | Mouse scFv |
| TAB-0590CL-F(E) | Mouse Anti-FCRL5 Recombinant Antibody; Fab Fragment (TAB-0590CL-F(E)) | ELISA, FC, WB | Mouse Fab |
| TAB-0591CL-F(E) | Mouse Anti-FCRL5 Recombinant Antibody; Fab Fragment (TAB-0591CL-F(E)) | ELISA, FC, WB | Mouse Fab |
| TAB-0592CL-F(E) | Mouse Anti-FCRL5 Recombinant Antibody; Fab Fragment (TAB-0592CL-F(E)) | ELISA, FC, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0016CQ | Human Anti-FCRL5 Recombinant Antibody (HPAB-0016CQ) | ELISA, WB, RIA | Human IgG1, κ |
| HPAB-0017CQ | Human Anti-FCRL5 Recombinant Antibody (HPAB-0017CQ) | ELISA, WB, RIA | Human IgG1, λ |
| HPAB-AP650-YC | Mouse Anti-FCRL5 Recombinant Antibody (HPAB-AP650-YC) | FC, FuncS | Mouse IgG |
| HPAB-AP651-YC | Human Anti-FCRL5 Recombinant Antibody (HPAB-AP651-YC) | FC, FuncS | Human IgG1 |
| HPAB-AP652-YC | Human Anti-FCRL5 Recombinant Antibody (HPAB-AP652-YC) | FC, FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0016CQ-S(P) | Human Anti-FCRL5 Recombinant Antibody; scFv Fragment (HPAB-0016CQ-S(P)) | ELISA, WB, RIA | Human scFv |
| HPAB-0017CQ-S(P) | Human Anti-FCRL5 Recombinant Antibody; scFv Fragment (HPAB-0017CQ-S(P)) | ELISA, WB, RIA | Human scFv |
| HPAB-0018CQ-S(P) | Human Anti-FCRL5 Recombinant Antibody; scFv Fragment (HPAB-0018CQ-S(P)) | RIA, ELISA | Humanized scFv |
| HPAB-0180CQ-S(P) | Human Anti-FCRL5 Recombinant Antibody (clone 9D12); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-0181CQ-S(P) | Human Anti-FCRL5 Recombinant Antibody (clone 8A1); scFv Fragment | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC616 | Recombinant Anti-FCRL5 Vesicular Antibody, EV Displayed (VS-0425-YC616) | ELISA, FC, Cell-uptake |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: WB, ELISA, FC, IP, FuncS, IF, Neut
Application: FuncS, IF, Neut, ELISA, FC, IP, WB
Application: Neut, ELISA, Inhib, ICC, WB
Application: ELISA, FC, IF, WB
Application: ELISA, Inhib, FuncS
-3.jpg)
Application: Neut
Application: FC
Application: ELISA, Block, WB, FC, IP
Application: ELISA, FuncS
Application: ELISA, WB
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
