17-GMB-APA-GA

Name: 17-GMB-APA-GA
SKU: ADCsR-179CL
Rating: 5 (1 reviews)

CAT#: ADCsR-179CL

17-GMB-APA-GA is an Geldanamycin analog equipped with linker for coupling to proteins or antibodies for the preparation of immunoconjugates, for example. This geldanamycin immunoconjugate induces less systemic toxicity than geldanamycin by being selectively delivered into malignant cells. This linker chain is just an example. We can also install other types of simpler side chains for example a chain with a free NH2 at its terminus. Reference: 1. R. Mandler et al. Cancer Res. 2004 64:1460; 2. R. Mandler et al. Bioconj. Chem. 2002 13:786; 3. R. Mandler et al. J. Natl. Cancer Inst. 2000 92:1573

Specifications

Longtext
17-(3-(4-Maleimidobutylcarboxamido)propopylamino)-demethoxygeldanamycin)

Formula
C39H53N5O11

Molecular Weight
767,90 g/mol

Purity
95%

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Datasheet

Datasheet - ADCsR-179CL.pdf

MSDS

MSDS - ADCsR-179CL.pdf

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