APC-A*02:01/Human Topo II (FLYDDNQRV) MHC Tetramer
CAT#: MHC-LC031
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of Topo II-derived peptide of FLYDDNQRV sequence covering 828-836 and A*02:01 molecule. The pMHC tetramer recognizes human CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/50441/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4601/if_selected.jpg
Normal Tissue
Figure 3 Breast
Adipocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Myoepithelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4601/11584_B_2_4.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: nuclear Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4601/11584_A_8_8.jpg
Normal Tissue
Figure 5 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Glial cells Staining: High Intensity: Strong Quantity:>75% Location: nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4601/11584_B_8_5.jpg
Normal Tissue
Figure 6 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4601/11584_A_9_3.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4601/11584_A_8_5.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (REH)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000077097-TOP2B
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Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- Topo II
- Antigen Species
- Human
- Peptide
- FLYDDNQRV
- Range
- 828-836
- Conjugate
- APC
- Application
- FCM
Target
- Antigen Introduction
- This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing results in multiple transcript variants.
- Alternative Names
- TOP2B; Topoisomerase (DNA) II beta; TOPIIB; top2beta
- Gene ID
- 7155
- UniProt ID
- Q02880
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MSDS
COA
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See other products for "TOP2B"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2066z | Mouse Anti-TOP2B Recombinant Antibody (clone 20B1) | WB, ELISA, IF, IP | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC030 | PE-A*02:01/Human Topo II (FLYDDNQRV) MHC Tetramer | FCM | |
| MHC-LC032 | BV421-A*02:01/Human Topo II (FLYDDNQRV) MHC Tetramer | FCM | |
| MHC-LC4346 | PE-B*07:02/Human TOP2B (SPRYIFTML) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3640 | Rabbit Anti-TOP2B Recombinant Antibody (clone DS3640AB) | WB, IHC, ICC | Rabbit IgG |
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