APC-B*44:03/Human ABCD3 (EEYLQAFTY) MHC Tetramer (CAT#: MHC-LC1488)

• Allele
• B*44:03

• Class
• Class I

• MHC Species
• Human

• Antigen
• ABCD3

• Antigen Species
• Human

• Peptide
• EEYLQAFTY

• Range
• 164-172

• Conjugate
• APC

• Application
• FCM

• Antigen Introduction
• The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

• Alternative Names
• ZWS2; ABC43; CBAS5; PMP70; PXMP1; ABCD3; ATP binding cassette subfamily D member 3

• Gene ID
• 5825

• UniProt ID
• P28288

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