Anti-B. anthracis anthrax protective antigen (Panobacumab) (CAT#: TAB-105)

Recombinant monoclonal antibody to P. aeruginosa. Panobacumab (proposed INN) is a monoclonal antibody designed as an antibacterial against P. aeruginosa. It is a fully human pentameric IgM antibody with a mouse J chain.

Host: Human

Isotype: IgM - kappa

Applications: WB, IP, IF, FuncS, FC, Neut, ELISA


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Figure 1 Reduced lung inflammation after Panobacumab treatment in immunosuppressed P. aeruginosa-infected mice.

B6 mice were immunosuppressed with cyclophosphamide (100 mg/kg) and 3 days later infected by intra-nasal instillation of 40 µL of P. aeruginosa strain 2310.55 (2x105 cfu). Panobacumab was given i.v. at 0.4 mg/kg, 4 h after the infection. Absolute numbers of cells (A), neutrophils (B) were measured in BALF 24 h after infection. Lung MPO (C) was recorded 24 h after infection. The concentrations of IL-6 (D) and IL-1β (E) in lung homogenates were determined 24 h after infection. Groups of 8-10 mice were used and mean values ± SEM are shown (One-way ANOVA with Tukey's Multiple Comparison Test: * p<0.05, *** p<0.001). The results are a pool of two independent experiments.

Secher, T., Fas, S., Fauconnier, L., Mathieu, M., Rutschi, O., Ryffel, B., & Rudolf, M. (2013). The anti-Pseudomonas aeruginosa antibody Panobacumab is efficacious on acute pneumonia in neutropenic mice and has additive effects with meropenem. PloS one, 8(9), e73396.


Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • IgM - kappa
  • Specificity
  • Tested positive against native P. aeruginosa antigen
  • Species Reactivity
  • P. aeruginosa
  • Applications
  • WB, IP, IF, FuncS, FC, Neut, ELISA
  • Trade name
  • aerumab 11
  • CAS
  • 885053-97-4
  • Generic Name
  • Panobacumab
  • UNII
  • 62B4OXU259
  • MW
  • 879.9 kDa
  • Related Disease
  • Pseudomonas aeruginosa, hospital acquired pneumonia caused by serotype 011 positive Pseudomonas aeruginosa

Product Property

  • Purity
  • >95.0% as determined by analysis by RP-HPLC.
  • Storage
  • Store at -20°C for long-term storage. Store at 2-8°C for up to one month. Avoid freeze/thaw cycles.

Applications

  • Application Notes
  • The Pseudomonas aeruginosa serotype IATS O11 antibody has been reported in applications of MPO.

Target

  • Alternative Names
  • Panobacumab;aerumab 11;885053-97-4;KBPA101;Pseudomonas aeruginosa;P Aeruginosa;P. Aeruginosa;IATS O11

Related Resources

  • Biosimilar Overview
Please refer to Panobacumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Panobacumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Panobacumab"

Afuco™ Anti-P. aeruginosa Serotype IATS O11 ADCC Recombinant Antibody (Panobacumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to P. aeruginosa. Panobacumab (proposed INN) is a monoclonal antibody designed as an antibacterial against P. aeruginosa. It is a fully human pentameric IgM antibody with a mouse J chain.

See other products for "P. aeruginosa Serotype IATS O11"

Single-domain Antibody

CAT Product Name Application Type
NAB-2050-VHH Recombinant Anti-Pseudomonas aeruginosa serotype IATS O11 VHH Single Domain Antibody IHC, IP, FC, Neut, FUNC Llama VHH

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-105 Afuco™ Anti-P. aeruginosa Serotype IATS O11 ADCC Recombinant Antibody (Panobacumab), ADCC Enhanced IP, IF, FuncS, FC, Neut ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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