Recombinant monoclonal antibody to P. aeruginosa. Panobacumab (proposed INN) is a monoclonal antibody designed as an antibacterial against P. aeruginosa. It is a fully human pentameric IgM antibody with a mouse J chain.
Isotype: IgM - kappa
Applications: WB, IP, IF, FuncS, FC, Neut, ELISA
Figure 1 Reduced lung inflammation after Panobacumab treatment in immunosuppressed P. aeruginosa-infected mice.
B6 mice were immunosuppressed with cyclophosphamide (100 mg/kg) and 3 days later infected by intra-nasal instillation of 40 µL of P. aeruginosa strain 2310.55 (2x105 cfu). Panobacumab was given i.v. at 0.4 mg/kg, 4 h after the infection. Absolute numbers of cells (A), neutrophils (B) were measured in BALF 24 h after infection. Lung MPO (C) was recorded 24 h after infection. The concentrations of IL-6 (D) and IL-1β (E) in lung homogenates were determined 24 h after infection. Groups of 8-10 mice were used and mean values ± SEM are shown (One-way ANOVA with Tukey's Multiple Comparison Test: * p<0.05, *** p<0.001). The results are a pool of two independent experiments.
Secher, T., Fas, S., Fauconnier, L., Mathieu, M., Rutschi, O., Ryffel, B., & Rudolf, M. (2013). The anti-Pseudomonas aeruginosa antibody Panobacumab is efficacious on acute pneumonia in neutropenic mice and has additive effects with meropenem. PloS one, 8(9), e73396.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
Afuco™ Anti-P. aeruginosa Serotype IATS O11 ADCC Recombinant Antibody (Panobacumab), ADCC EnhancedThis product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to P. aeruginosa. Panobacumab (proposed INN) is a monoclonal antibody designed as an antibacterial against P. aeruginosa. It is a fully human pentameric IgM antibody with a mouse J chain.
|NAB-2050-VHH||Recombinant Anti-Pseudomonas aeruginosa serotype IATS O11 VHH Single Domain Antibody||IHC, IP, FC, Neut, FUNC||Llama VHH|
|AFC-TAB-105||Afuco™ Anti-P. aeruginosa Serotype IATS O11 ADCC Recombinant Antibody (Panobacumab), ADCC Enhanced||IP, IF, FuncS, FC, Neut||ADCC enhanced antibody|
Submit a review or a question
There are currently no Customer reviews or questions for TAB-105. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.