Anti-Human CLDN3 Recombinant Antibody (Chimeric CDN04)
CAT#: TAB-495LC
Recombinant monoclonal antibody to CLDN3. Chimeric CDN04 is a chimeric anitbody (mouse/human) that can be potentially used in the treatment of ovarian cancer, prostate cancer and breast cancer.
Published Data
Tested Data
Gene Expression
Cyt
Figure 1 shows the anti-Claudin 3 antibody-mediated induction of complement-dependent cytotoxic activity against MCF7 cells. The vertical axis indicates the specific chromium release rate (%).
FC
Figure 2 shows, by flow cytometry, the specific binding of recombinant chimeric antibodies to cells forced to express Claudin 3. The vertical axis indicates cell count (fluorescence coefficient), and the horizontal axis indicates fluorescence intensity.
Inhib
Figure 3 is a graph showing suppression of the proliferation of MCF7 cells by anti-Claudin 3 antibodies in a soft agar colony formation/MTT hybrid assay.
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SDS-PAGE
Figure 1 Anti-Human CLDN3 Antibody in SDS-PAGE
SDS-PAGE analysis of TAB-495LC in non-reduced (Lane 1) and reduced (Lane 2) conditions.
HPLC
Figure 2 Anti-Human CLDN3 Antibody in HPLC
HPLC analysis of TAB-495LC shows that the purity is more than 95%.
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Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to cell junctions.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14361/1661_D5_4_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14361/33701_B_8_5.jpg
Normal Tissue
Figure 3 Small intestine
Endocrine cells
Staining:High
Intensity: Strong
Enterocytes
Staining:High
Intensity: Strong
Quantity:>75%
Enterocytes - Microvilli
Staining:High
Intensity: Strong
Goblet cells
Staining:High
Intensity: Strong
Quantity:>75%
Paneth cells
Staining:High
Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14361/33701_A_4_2.jpg
Normal Tissue
Figure 4 Colon
Endocrine cells
Staining:High
Intensity: Strong
Enterocytes
Staining:High
Intensity: Strong
Quantity:>75%
Enterocytes - Microvilli
Staining:High
Intensity: Strong
Goblet cells
Staining:High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14361/33701_A_7_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14361/33701_A_8_4.jpg
Normal Tissue
Figure 6 Kidney
Bowman's capsule
Staining:High
Intensity: Strong
Quantity:>75%
Collecting ducts
Staining:High
Intensity: Strong
Quantity:>75%
Distal tubules
Staining:High
Intensity: Strong
Quantity:>75%
Proximal tubules (cell body)
Staining:Medium
Intensity: Strong
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14361/33701_A_9_5.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (MCF7, PC-3, RPMI-8226, SCLC-21H, T-47d)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000165215-CLDN3
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Specifications
- Host Species
- Human
- Derivation
- Chimeric (mouse/human)
- Type
- Chimeric antibody (mouse/human)
- Specificity
- Human
- Clone
- Chimeric CDN04
- Applications
- Cyt, FC, Inhib
- Related Disease
- Ovarian cancer, Prostate cancer, Breast cancer
Product Property
- Preservative
- Human
- Storage
- CLDN3 (claudin 3)
Applications
- Application Notes
- This antibody has been reported for use in Cytotoxicity, Flow Cytometry, Inhibition.
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone Chimeric CDN04"
- CAT
- Product Name
See other products for "CLDN3"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-610-VHH | Recombinant Anti-Human CLDN3 VHH Single Domain Antibody | ELISA, Neut, ICC, FC | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-495LC-F(E) | Anti-Human CLDN3 Recombinant Antibody Fab Fragment (Chimeric CDN04) | FC, ELISA | Chimeric antibody (mouse/human) |
| TAB-496LC-F(E) | Anti-Human CLDN3 Recombinant Antibody Fab Fragment (Chimeric CDN16) | FC, ELISA | Chimeric antibody (mouse/human) |
| TAB-497LC-F(E) | Anti-Human CLDN3 Recombinant Antibody Fab Fragment (Chimeric CDN27) | FC, ELISA | Chimeric antibody (mouse/human) |
| TAB-498LC-F(E) | Anti-Human CLDN3 Recombinant Antibody Fab Fragment (Chimeric CDN28) | FC, ELISA | Chimeric antibody (mouse/human) |
| TAB-499LC-F(E) | Anti-Human CLDN3 Recombinant Antibody Fab Fragment (Chimeric CDN35) | FC, ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0150-LSX | Mouse Anti-CLDN3 Recombinant Antibody (clone CDN08) | ELISA, FC, FC | Mouse IgG2b, κ |
| HPAB-0151-LSX | Mouse Anti-CLDN3 Recombinant Antibody (clone CDN16) | ELISA, FC, FC | Mouse IgG2b, κ |
| VS3-FY390 | Recombinant Mouse Anti-CLDN3 Antibody (clone 10F10-3E3-8G5) | IHC-P | Mouse IgG1 |
| VS3-FY391 | Recombinant Rabbit Anti-CLDN3 Antibody (clone R08-4F8) | WB, ICC, IF, IP | Rabbit IgG |
| VS3-FY2669 | Rabbit Anti-CLDN3 Recombinant Antibody (VS3-FY2669) | WB, ICC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0150-LSX-S(P) | Mouse Anti-CLDN3 Recombinant Antibody (clone CDN08); scFv Fragment | ELISA, FC, FC | Mouse scFv |
| HPAB-0151-LSX-S(P) | Mouse Anti-CLDN3 Recombinant Antibody (clone CDN16); scFv Fragment | ELISA, FC, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0150-LSX-F(E) | Mouse Anti-CLDN3 Recombinant Antibody (clone CDN08); Fab Fragment | ELISA, FC, FC | Mouse Fab |
| HPAB-0151-LSX-F(E) | Mouse Anti-CLDN3 Recombinant Antibody (clone CDN16); Fab Fragment | ELISA, FC, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC133 | Recombinant Anti-CLDN3 Vesicular Antibody, EV Displayed (VS-0425-YC133) | Cyt, ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1484 | Anti-CLDN3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1485 | Anti-Human CLDN3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1486 | Anti-Mouse CLDN3 Immunohistochemistry Kit | IHC |
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