Recombinant Human Anti-CMV gH Antibody (MSL-109) (CAT#: PABL-049)
Recombinant Human Antibody (MSL-109) is capable of binding to CMV gH, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-CMV gH mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-CMV gH mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody could prevent infection of cells.
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We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Neut
Figure 1 Neutralization assays with MSL-109 antibodies on MSL-109–resistant strains in epithelial cells (ARPE-19).
Antibody was serially diluted and mixed with a fixed amount of virus, such that the final virion concentration was a MOI of 1. Cells were infected for 18 h and quantitated using immunofluorescence with an anti–CMV-IE antibody. Data were log-transformed, normalized to infection without antibody, and graphed using Prism.
Fouts, A. E., Comps-Agrar, L., Stengel, K. F., Ellerman, D., Schoeffler, A. J., Warming, S., ... & Feierbach, B. (2014). Mechanism for neutralizing activity by the anti-CMV gH/gL monoclonal antibody MSL-109. Proceedings of the National Academy of Sciences, 111(22), 8209-8214.
FC
Figure 2 FACS profiles of MSL-109 antibody binding to cell-surface expressed gH/gL.
COS-7 cells were transfected with plasmids bearing wild-type or mutated gH/gL/eGFP.
Fouts, A. E., Comps-Agrar, L., Stengel, K. F., Ellerman, D., Schoeffler, A. J., Warming, S., ... & Feierbach, B. (2014). Mechanism for neutralizing activity by the anti-CMV gH/gL monoclonal antibody MSL-109. Proceedings of the National Academy of Sciences, 111(22), 8209-8214.
Specifications
- Immunogen
- Cytomegalovirus glycoprotein H
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native CMV gH
- Species Reactivity
- CMV
- Clone
- MSL-109
- Applications
- Neut, FC
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- This antibody has been reported for use in Neutralization and Flow Cytometry.
Target
- Alternative Names
- glycoprotein H; gH
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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ScFv Antibody Products
Fab Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-049 | Recombinant Human Anti-CMV gH Antibody scFv Fragment (MSL-109) | WB, Neut, FuncS | scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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