anti-CRH immunotoxin PFU 83 (IgG)-RTA (CAT#: AGTO-L007R)
This immunotoxin was achieved by conjugating/fusing the Anti-CRH monoclonal antibody to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to CRF neurons cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of Anorexia nervosa.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (SuSa)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000147571-CRH
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000147571-CRH
Specifications
- Host Species
- Rat
- Species Reactivity
- Human
- Clone
- PFU 83
- Molecule Class
- L kappa; IgG2a-RTA
- Toxin Description
- Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Anorexia nervosa
Target
- Alternative Names
- CRH; corticotropin releasing hormone; CRF; CRH1; corticoliberin; corticotropin-releasing factor; Anorexia nervosa; Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA
- Gene ID
- 1392
- UniProt ID
- P06850
Related Resources
Alcoholism
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone PFU 83"
See other products for "CRH"
Select a product category from the dropdown menu below to view related products.
Please select product type
IgG Antibody Products
Chicken IgY Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2504z | Mouse Anti-CRH Recombinant Antibody (clone 8F1) | WB, ELISA, IP | Mouse IgG2a, κ |
| MOB-1700MZ | Recombinant Mouse Anti-Human CRH Antibody (clone 5I0) | ELISA, IHC-Fr, IHC-P | Mouse antibody |
Customer Reviews and Q&As
Customer Review
Q&As
Benchmark for Specificity
This antibody has established a standard for specificity in our laboratory. There are no cross-reactions, and the results are clear-it's ideal for our needs.
User-friendly
The antibody is easy to use and effective in a wide range of applications. Preparation and use are both uncomplicated.
Excellent Support
Customer care was extremely prompt and provided effective answers to all of our technical questions. This type of support is quite beneficial.
Popular products with customers
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: WB, Neut, FuncS
Application: WB, ELISA, FuncS
-3.jpg)
Application: ELISA, FC, WB, Block
Application: SPR, Inhib, FuncS
Application: ELISA, FuncS
Application: ELISA, FC, IF, IHC, WB
Application: WB, FC, IF, Inhib, ELISA, IHC
Application: IF, IP, Neut, FuncS, ELISA, FC
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
