Anti-FOLR2 immunotoxin (IgG)-PE
CAT#: AGTO-G031E
This immunotoxin was achieved by conjugating/fusing the Anti-FOLR2 monoclonal antibody to Pseudomonas exotoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to folate receptor β (FRβ)–expressing cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis. It was designed for treating rheumatoid arthritis.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enriched (U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000165457-FOLR2
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Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Molecule Class
- IgG-PE
- Toxin Description
- Pseudomonas aeruginosa exotoxin (Pseudomonas Aeruginosa Exotoxin A, PE) is a cell toxin produced by P. aeruginosa. Divided into three domains in space. DomainIII (s 405~613 amino acids) having ADP ribosylation activity, can inhibit protein synthesis, PE on toxicity mechanisms of cell depends on its Domainlll. After PE molecules into mammals, Domain Ia and widely distributed in mammalian cells α 2 macroglobulin receptor binding was endocytic, then PE cleaved fragments the size of Mr 37000 and 27000, the large fragment and finally into the Golgi and elongation factor 2 (EM) combining it glycosylation inactivation, inhibition of protein synthesis, leading to apoptosis.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- rheumatoid arthritis
Target
- Alternative Names
- FOLR2; folate receptor 2 (fetal); FBP; FR-P3; FR-BETA; BETA-HFR; FBP/PL-1; folate receptor beta; folate receptor, beta; folate receptor, fetal/placental; placental folate-binding protein; folate-binding protein, fetal/placental; Pseudomonas exotoxin; Pseudomonas exotoxin A; Pseudomonas aeruginosa exotoxin; Pseudomonas aeruginosa exotoxin A; PE; PE38; PE40; ETA; PE33; PE57
- Gene ID
- 2350
- UniProt ID
- P14207
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
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See other products for "FOLR2"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-022CQ | Anti-Human FOLR2 Recombinant Antibody (36) | ELISA, WB | |
| TAB-022CQ-S(P) | Anti-Human FOLR2 Recombinant Antibody scFv Fragment (36) | ELISA, WB | |
| TAB-023CQ-S(P) | Anti-Human FOLR2 Recombinant Antibody scFv Fragment (94b) | ELISA, WB | |
| TAB-022CQ-F(E) | Anti-Human FOLR2 Recombinant Antibody Fab Fragment (36) | ELISA, WB | |
| TAB-023CQ-F(E) | Anti-Human FOLR2 Recombinant Antibody Fab Fragment (94b) | ELISA, WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0757CT | Recombinant Mouse anti-Human FOLR2 Monoclonal antibody (4G6) | ELISA, WB | |
| FAMAB-0143CQ | Mouse Anti-Folr2 Recombinant Antibody (clone 4A67) | ELISA, FC | Mouse IgG |
| VS3-CJ648 | Mouse Anti-FOLR2 Recombinant Antibody (VS3-CJ648) | WB | Mouse IgG2b, κ |
| VS-0723-WK145 | Human Anti-FOLR2 Recombinant Antibody (VS-0723-WK145) | FC | Chimeric (rabbit/human) IgG1 |
| VS3-FY2711 | Mouse Anti-FOLR2 Recombinant Antibody (VS3-FY2711) | WB | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1334 | Hi-Affi™ Rabbit Anti-FOLR2 Recombinant Antibody (clone DS1334AB) | ELISA | Rabbit IgG |
| MOR-4183 | Hi-Affi™ Rabbit Anti-FOLR2 Recombinant Antibody (clone SI260DS) | WB, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0143CQ-F(E) | Mouse Anti-Folr2 Recombinant Antibody (clone 4A67); Fab Fragment | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0143CQ-S(P) | Mouse Anti-Folr2 Recombinant Antibody (clone 4A67); scFv Fragment | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC746 | Recombinant Anti-Folr2 Vesicular Antibody, EV Displayed (VS-0425-YC746) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2607 | Anti-FOLR2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2608 | Anti-Mouse FOLR2 Immunohistochemistry Kit | IHC |
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