Mouse Anti-HIV-2 Recombinant Antibody (clone 7C8) (CAT#: PABX-104)
Anti-HIV-2 antibody is a Mouse antibody of IgG class that binds to an HIV-2.
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Figure 1 Western blot analysis of 7C8 and 3C4 binding to the different glycoproteins.
a) Recognition of gp125 (I) and gp125Δv1v2 (II) by 7C8 in nonreducing conditions. Oligomers recognized by 7C8 are indicated by arrows. b) 7C8 binding to gp125 (I) and gp125Δv1v2 (II) in reducing conditions. c) GN-purified gp125 (I) and gp125Δv1v2 (II) recognition by 3C4 in non-reducing conditions. Oligomers are indicated by arrows.
Sourial, S., Nilsson, C., Warnmark, A., Achour, A., & Harris, R. A. (2006). Deletion of the V1/V2 region does not increase the accessibility of the V3 region of recombinant gp125. Current HIV research, 4(2), 229-237.
Figure 2 SPR analysis of 7C8 and CD4 binding to the different glycoproteins.
a) 7C8 binding to equimolar amounts of gp125 (bold) and gp125Δv1v2 (dashed) immobilized onto individual surfaces of a CM5 chip, b) CD4 binding to equimolar amounts of HIV-1 gp120 (light), gp125Δv1v2 (bold),or gp125 (dashed)CM5 immobilized on CM5 chip surfaces.
Sourial, S., Nilsson, C., Warnmark, A., Achour, A., & Harris, R. A. (2006). Deletion of the V1/V2 region does not increase the accessibility of the V3 region of recombinant gp125. Current HIV research, 4(2), 229-237.
Figure 3 Overall three-dimensional structure of the HIV-2 neutralizing Fab fragment 7C8.
A) Overall view of the crystal structure of the 7C8 Fab fragment. The light and heavy chains are displayed in light and dark grey, respectively. The six CDR loops are in dark blue (CDRL1), light blue (CDRL2), blue (CDRL3), brown (CDRH1), red (CDRH2) and pink (CDRH3). A black dashed line indicates the disordered loop within the first constant region of the CH1 domain. B) Stick representation of the stretch of residues 93 to 100C corresponding to the unusually long third complementary determining region of the heavy chain (CDRH3) with the electron density carved around the model at 1.2 s. C) Ribbon representation of the two monomers found in the assymmetric unit indicating the large variation in elbow angle.
Uchtenhagen, H., Friemann, R., Raszewski, G., Spetz, A. L., Nilsson, L., & Achour, A. (2011). Crystal structure of the HIV-2 neutralizing Fab fragment 7C8 with high specificity to the V3 region of gp125. PloS one, 6(4), e18767.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Tested positive against HIV-2
- Species Reactivity
- HIV-2
- Clone
- 7C8
- Applications
- WB 1:1000-1:5000
ELISA 1:3000-1:15000
FuncS (Assay-dependent)
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Assay-dependent
Target
- Alternative Names
- HIV-1; human immunodeficiency virus-2
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Mouse Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-495 | Recombinant Anti-HIV-2 Antibody | ELISA, WB, Dot, FuncS | IgG |
| MHH-495 | Recombinant Human Anti-HIV-2 Antibody | ELISA, WB, IF, FuncS | IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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