Rat Anti-Il6ra Recombinant Antibody (clone D7715A7)
CAT#: NEUT-1494CQ
This antibody is a rat monoclonal antibody that binds specifically to IL-6Rα chain, and it can neutralize the bioactivity of IL-6Rα chain.
Specifications
- Immunogen
- OKT4 hybridoma cells
- Host Species
- Rat
- Type
- Rat IgG2b, κ
- Specificity
- Mouse and Rat Il6ra
- Species Reactivity
- Mouse, Rat
- Clone
- D7715A7
- Applications
- FC, IP, Neut
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Neutralizes IL-6R Alpha
We needed a rat monoclonal antibody to neutralize the bioactivity of the IL-6R alpha chain, and clone D7715A7 was effective. It binds specifically to the receptor and inhibited downstream signaling in our experimental setup.
Specific For Mouse/Rat
This antibody cross-reacts with both mouse and rat IL6RA, which is very convenient for our comparative studies. We used it for flow cytometry and IP, and the results were consistent and reliable across species.
Q&As
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Does this antibody cross-react with other species?
A: Yes, this rat monoclonal antibody (clone D7715A7) binds specifically to both Mouse and Rat IL6RA (Interleukin 6 receptor alpha chain). This cross-reactivity makes it a useful tool for comparative research between these rodent models.
-
Can this antibody block IL-6 receptor function?
A: Yes, this antibody can neutralize the bioactivity of the IL-6Rα chain. By binding to the receptor, it can inhibit signal transduction that typically necessitates association with IL6ST, making it valuable for functional inhibition studies.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Il6ra"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1495CQ | Rat Anti-Il6ra Recombinant Antibody (NEUT-1495CQ) | Block, FC, IP | Rat IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1496CQ | Rat Anti-Il6ra Recombinant Antibody (clone 15A7) | Block | Rat IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4008 | Rabbit Anti-Il6ra Recombinant Antibody (clone SI70DS) | ICC, IF, IF, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4009 | Rabbit Anti-Il6ra Recombinant Antibody (clone SI71DS) | FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4278 | Rabbit Anti-Il6ra Recombinant Antibody (clone SI361DS) | ELISA | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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