Anti-Influenza A Virus H1N1 Hemagglutinin HA1 subunit Recombinant Antibody (MRO-247LC-VHH) (CAT#: MRO-247LC-VHH)
This product is a recombinant alpaca anti-influenza A virus H1N1 single domain antibody. R2a-H9 specifically binds to hemagglutinin HA1 subunit and can be potentially usd in the treatment of influenza virus infection.
Specific Inquiry
ELISA
Figure 1 Specificity of single domain antibodies to different influenza antigen reference reagents.
ELISA comparing binding of purified VHH antibodies at 30 mg/ml against H1N1, seasonal H1N1 and H5N1.
Hufton, S. E., Risley, P., Ball, C. R., Major, D., Engelhardt, O. G., & Poole, S. (2014). The breadth of cross sub-type neutralisation activity of a single domain antibody to influenza hemagglutinin can be increased by antibody valency. PLoS One, 9(8), e103294.
SPR
Figure 2 Antibody affinity on recombinant HA by surface plasmon resonance.
Affinity on recombinant H1-HA, H1N1.
Hufton, S. E., Risley, P., Ball, C. R., Major, D., Engelhardt, O. G., & Poole, S. (2014). The breadth of cross sub-type neutralisation activity of a single domain antibody to influenza hemagglutinin can be increased by antibody valency. PLoS One, 9(8), e103294.
ELISA
Figure 3 Characterisation of antibody epitopes.
ELISA showing reactivity of purified antibodies at 30 mg/ml to HA antigen standard H1N1 either treated with low pH or neutral pH.
Hufton, S. E., Risley, P., Ball, C. R., Major, D., Engelhardt, O. G., & Poole, S. (2014). The breadth of cross sub-type neutralisation activity of a single domain antibody to influenza hemagglutinin can be increased by antibody valency. PLoS One, 9(8), e103294.
ELISA
Figure 4 Characterisation of antibody epitopes.
ELISA showing binding of phage displayed HA gene fragments to purified sdAbs.
Hufton, S. E., Risley, P., Ball, C. R., Major, D., Engelhardt, O. G., & Poole, S. (2014). The breadth of cross sub-type neutralisation activity of a single domain antibody to influenza hemagglutinin can be increased by antibody valency. PLoS One, 9(8), e103294.
Specifications
- Host Species
- Alpaca
- Derivation
- Phage display library
- Type
- Single domain antibody
- Specificity
- Influenza A virus H1N1
- Clone
- MRO-247LC-VHH
- Applications
- ELISA, SPR
- Related Disease
- Influenza virus infections
Applications
- Application Notes
- The antibody was validated for ELISA, Surface plasmon resonance. For details, refer to Published Data.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Single Domain Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-229LC-VHH | Anti-Influenza A Virus H1N1 Hemagglutinin HA1 subunit Recombinant Antibody (MRO-229LC-VHH) | ELISA, SPR | Single domain antibody |
| MRO-230LC-VHH | Anti-Influenza A Virus H1N1 Hemagglutinin HA1 subunit Recombinant Antibody (MRO-230LC-VHH) | ELISA, SPR | Single domain antibody |
| MRO-231LC-VHH | Anti-Influenza A Virus H1N1 Hemagglutinin HA1 subunit Recombinant Antibody (MRO-231LC-VHH) | ELISA, FuncS, SPR, FC | Single domain antibody |
| MRO-232LC-VHH | Anti-Influenza A Virus H1N1 Hemagglutinin HA1 subunit Recombinant Antibody (MRO-232LC-VHH) | ELISA, FuncS, SPR, FC | Single domain antibody |
| MRO-233LC-VHH | Anti-Influenza A Virus H1N1 Hemagglutinin HA1 subunit Recombinant Antibody (MRO-233LC-VHH) | ELISA, SPR | Single domain antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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