Recombinant Anti-KSHV LANA1 Intrabody [(D-Arg)9]
CAT#: IAB-B041(A)
Recombinant anti-KSHV LANA1 intrabody linked to (D-Arg)9 works within cells and binds specifically to KSHV LANA1, expressed in E. coli cells. It can bind N-terminal LANA1 epitopes and neutralize the chromosome-binding activity of LANA1.
Specifications
- Immunogen
- herpesvirus (KSHV) latency-associated nuclear antigen-1
- Host Species
- rabbit
- Type
- scFv-(D-Arg)9
- Cell Penetrating Peptide
- (D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
- Species Reactivity
- KSHV
- Applications
- Antibody assay: Enzyme-linked Immunosorbent Assay; Western blot; Immunocytochemistry; Functional studies
Product Property
- Purity
- 95% by HPLC
- Storage
- Store at -20°C. Avoid multiple freeze/thaw cycles.
Target
- Alternative Names
- KSHV LANA1; herpesvirus (KSHV) latency-associated nuclear antigen-1
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B041(G) | Recombinant Anti-KSHV LANA1 Intrabody [+36 GFP] | IF, FC, WB, FuncS | scFv-(+36GFP) |
| IAB-B041(T) | Recombinant Anti-KSHV LANA1 Intrabody [Tat] | WB, CO-IP, FuncS | scFv-Tat |
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