Anti-Human LIGHT Recombinant Antibody (14G8) (CAT#: TAB-0679CL)
Antibody 14G8 is a mouse monoclonal antibody that specifically binds to human LIGHT. It can inhibit human and cynomolgus LIGHT-induced cell apoptosis in the colon carcinoma cell line HT-29.
Specific Inquiry
Inhib
Figure 1 Inhibition of T-cell proliferation and cytokine production by treatment with SEB specific mAb 20B1, 14G8, 6D3, and 4C7 individually or in different combinations.
SEB-induced T-cell proliferation was measured by ViaLight HS Cell Proliferation kit after 48 h and inhibited in the presence of all three mAb except 4C7. IFN (C) and IL-2 (D) were measured by ELISA in the supernatant of SEB stimulated T-cells. Cytokines were significantly lower in the presence of mAbs relative to conditions with no specific antibody.
Varshney, A. K., Wang, X., Cook, E., Dutta, K., Scharff, M. D., Goger, M. J., & Fries, B. C. (2011). Generation, characterization, and epitope mapping of neutralizing and protective monoclonal antibodies against staphylococcal enterotoxin B-induced lethal shock. Journal of Biological Chemistry, 286(11), 9737-9747.
WB
Figure 2 Western blot analysis of mAbs 20B1, 14G8, 6D3, and 4C7 shows specificity of mAbs for SEB and not for SEA and TSST.
Varshney, A. K., Wang, X., Cook, E., Dutta, K., Scharff, M. D., Goger, M. J., & Fries, B. C. (2011). Generation, characterization, and epitope mapping of neutralizing and protective monoclonal antibodies against staphylococcal enterotoxin B-induced lethal shock. Journal of Biological Chemistry, 286(11), 9737-9747.
Specifications
- Host Species
- Mouse
- Specificity
- Human
- Clone
- 14G8
- Applications
- Inhib, WB, ELISA
- Related Disease
- Inflammatory bowel disease, Crohn's disease, ulcerative colitis, multiple sclerosis, rheumatoid arthritis and transplantation
Applications
- Application Notes
- The LIGHT antibody has been reported in applications of Inhibition, Western Blot, Enzyme-linked Immunosorbent Assay.
Target
- Alternative Names
- lymphotoxin-like; LIGHT
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone 14G8"
See other products for "LIGHT"
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0666CL-S(P) | Mouse Anti-LIGHT Recombinant Antibody; scFv Fragment (TAB-0666CL-S(P)) | ELISA | Mouse scFv |
| TAB-0667CL-S(P) | Mouse Anti-LIGHT Recombinant Antibody; scFv Fragment (TAB-0667CL-S(P)) | ELISA | Mouse scFv |
| TAB-0668CL-S(P) | Mouse Anti-LIGHT Recombinant Antibody; scFv Fragment (TAB-0668CL-S(P)) | ELISA | Mouse scFv |
| TAB-0669CL-S(P) | Mouse Anti-LIGHT Recombinant Antibody; scFv Fragment (TAB-0669CL-S(P)) | ELISA | Mouse scFv |
| TAB-0670CL-S(P) | Mouse Anti-LIGHT Recombinant Antibody; scFv Fragment (TAB-0670CL-S(P)) | ELISA | Mouse scFv |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0723-WK235 | Rabbit Anti-LIGHT Recombinant Antibody (VS-0723-WK235) | ELISA, FC | Rabbit IgG |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for TAB-0679CL. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.