Anti-PS Antibody-Cytokine Fusion Protein, IgG (2aG4)-IL2
CAT#: ACFP-SH006
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-PS IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the PS as well as the biological activity of IL2. 2aG4-IL2 has great improvement than 2aG4 and IL2 alone. First, the improvement is antigen-specific indicating that 2aG4-IL2 blocks PS-dependent immunosuppressive signals. Second, the improvement is greater with 2aG4-IL2 than with 2aG4 alone, indicating that immunostimulatory cytokine-IL2 contributes to the vaccination. This immunocytokine was designed for treating PS-expressing tumor.
Specifications
- Target
- PS
- Molecule Class
- IgG-IL2
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- 2aG4
- Related Disease
- PS-expressing tumor
- Cytokine 1
- IL2
- Cytokines 1 Description
- Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
- Cytokine 1 Species
- Mouse
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- Phosphatidyl Serine; Phosphatidylserine; Ptd-L-Ser; PS
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See other products for "PS"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-819 | Recombinant Anti-PS Antibody | ELISA, WB, Dot, FuncS | IgG |
| MHH-819 | Recombinant Human Anti-PS Antibody | WB, IP, FuncS | IgG |
| PABZ-170 | Human Anti-PS Recombinant Antibody (clone pSTAb) | ELISA, WB | Humanized IgG |
| PABZ-172 | Human Anti-PS Recombinant Antibody (clone pSAb) | ELISA, WB | Humanized IgG |
| MOB-066LC | Recombinant Human Anti-PS Therapeutical Antibody (MOB-066LC) | ELISA, FC, FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-819-F(E) | Recombinant Anti-PS Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
| MHH-819-F(E) | Recombinant Human Anti-PS Antibody Fab Fragment | WB, Dot, FuncS | Fab |
| FAMAB-0255-YC-F(E) | Mouse Anti-PS Recombinant Antibody (clone PS4A7); Fab Fragment | ELISA | Mouse Fab |
| FAMAB-0256-YC-F(E) | Mouse Anti-PS Recombinant Antibody (clone PS3A); Fab Fragment | ELISA | Mouse Fab |
| FAMAB-0257-YC-F(E) | Mouse Anti-PS Recombinant Antibody (clone PSC8); Fab Fragment | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-819-S(P) | Recombinant Anti-PS Antibody scFv Fragment | ELISA, IF, FuncS | scFv |
| MHH-819-S(P) | Recombinant Human Anti-PS Antibody scFv Fragment | WB, Neut, FuncS | scFv |
| FAMAB-0255-YC-S(P) | Mouse Anti-PS Recombinant Antibody (clone PS4A7); scFv Fragment | ELISA | Mouse scFv |
| FAMAB-0256-YC-S(P) | Mouse Anti-PS Recombinant Antibody (clone PS3A); scFv Fragment | ELISA | Mouse scFv |
| FAMAB-0257-YC-S(P) | Mouse Anti-PS Recombinant Antibody (clone PSC8); scFv Fragment | ELISA | Mouse scFv |
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