Anti-PS Antibody-Cytokine Fusion Protein, IgG (2aG4)-IL2 (CAT#: ACFP-SH006)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-PS IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the PS as well as the biological activity of IL2. 2aG4-IL2 has great improvement than 2aG4 and IL2 alone. First, the improvement is antigen-specific indicating that 2aG4-IL2 blocks PS-dependent immunosuppressive signals. Second, the improvement is greater with 2aG4-IL2 than with 2aG4 alone, indicating that immunostimulatory cytokine-IL2 contributes to the vaccination. This immunocytokine was designed for treating PS-expressing tumor.
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Specifications
- Target
- PS
- Molecule Class
- IgG-IL2
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- 2aG4
- Related Disease
- PS-expressing tumor
- Cytokine 1
- IL2
- Cytokines 1 Description
- Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
- Cytokine 1 Species
- Mouse
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- Phosphatidyl Serine; Phosphatidylserine; Ptd-L-Ser; PS
Downloads
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Mouse Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-819 | Recombinant Anti-PS Antibody | ELISA, WB, Dot, FuncS | IgG |
| MHH-819 | Recombinant Human Anti-PS Antibody | WB, IP, FuncS | IgG |
| PABZ-170 | Human Anti-PS Recombinant Antibody (clone pSTAb) | ELISA, WB | Humanized IgG |
| PABZ-172 | Human Anti-PS Recombinant Antibody (clone pSAb) | ELISA, WB | Humanized IgG |
| PABZ-173 | Human Anti-PS Recombinant Antibody (clone pYAb) | ELISA, WB | Humanized IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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