This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-PS IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the PS as well as the biological activity of IL2. 2aG4-IL2 has great improvement than 2aG4 and IL2 alone. First, the improvement is antigen-specific indicating that 2aG4-IL2 blocks PS-dependent immunosuppressive signals. Second, the improvement is greater with 2aG4-IL2 than with 2aG4 alone, indicating that immunostimulatory cytokine-IL2 contributes to the vaccination. This immunocytokine was designed for treating PS-expressing tumor.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-819 | Recombinant Anti-PS Antibody | ELISA, WB, Dot, FuncS | IgG |
FAMAB-0256YC | Mouse Anti-PS Recombinant Antibody (clone PS3A) | ELISA | Mouse IgG |
FAMAB-0257YC | Mouse Anti-PS Recombinant Antibody (clone PSC8) | ELISA | Mouse IgG |
HPAB-1899-FY | Mouse Anti-PS Recombinant Antibody (HPAB-1899-FY) | Inhib, FuncS, ELISA, WB, IF | Mouse IgG3, κ |
FAMAB-0104JF | Mouse Anti-PS Recombinant Antibody (clone 78.2) | WB, ELISA | Mouse IgG2b, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-819-F(E) | Recombinant Anti-PS Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
MHH-819-F(E) | Recombinant Human Anti-PS Antibody Fab Fragment | WB, Dot, FuncS | Fab |
PSBZ-170 | Human Anti-PS Recombinant Antibody (clone pSTAb); scFv Fragment | ELISA, WB | Humanized scFv |
PSBZ-172 | Human Anti-PS Recombinant Antibody (clone pSAb); scFv Fragment | ELISA, WB | Humanized scFv |
FAMAB-0104JF-F(E) | Mouse Anti-PS Recombinant Antibody (clone 78.2); Fab Fragment | DB, FELISA, ELISA, FuncS | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0255-YC-S(P) | Mouse Anti-PS Recombinant Antibody (clone PS4A7); scFv Fragment | ELISA | Mouse scFv |
FAMAB-0256-YC-S(P) | Mouse Anti-PS Recombinant Antibody (clone PS3A); scFv Fragment | ELISA | Mouse scFv |
FAMAB-0257-YC-S(P) | Mouse Anti-PS Recombinant Antibody (clone PSC8); scFv Fragment | ELISA | Mouse scFv |
HPAB-1899-FY-F(E) | Mouse Anti-PS Recombinant Antibody; Fab Fragment (HPAB-1899-FY-F(E)) | ELISA, Inhib | Mouse Fab |
FAMAB-0104JF-S(P) | Mouse Anti-PS Recombinant Antibody (clone 78.2); scFv Fragment | DB, FELISA, ELISA, FuncS | Mouse scFv |
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