Anti-PS Antibody-Cytokine Fusion Protein, IgG (2aG4)-IL2
CAT#: ACFP-SH006
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-PS IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the PS as well as the biological activity of IL2. 2aG4-IL2 has great improvement than 2aG4 and IL2 alone. First, the improvement is antigen-specific indicating that 2aG4-IL2 blocks PS-dependent immunosuppressive signals. Second, the improvement is greater with 2aG4-IL2 than with 2aG4 alone, indicating that immunostimulatory cytokine-IL2 contributes to the vaccination. This immunocytokine was designed for treating PS-expressing tumor.
Specifications
- Target
- PS
- Molecule Class
- IgG-IL2
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- 2aG4
- Related Disease
- PS-expressing tumor
- Cytokine 1
- IL2
- Cytokines 1 Description
- Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
- Cytokine 1 Species
- Mouse
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- Phosphatidyl Serine; Phosphatidylserine; Ptd-L-Ser; PS
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Superior To Antibody Alone
Our comparison data shows that 2aG4-IL2 offers a distinct improvement over using 2aG4 alone. The immunostimulatory cytokine clearly contributes to the vaccination effect we are studying in PS-expressing tumor microenvironments, validating the fusion design.
Blocking Immunosuppressive Signals
This product was instrumental in our study of PS-dependent signaling. It successfully blocked immunosuppressive signals in an antigen-specific manner, which was the primary metric for our current project on tumor vasculature markers.
Q&As
-
How does the fusion compare to using the antibody alone?
A: The 2aG4-IL2 fusion shows greater improvement than 2aG4 and IL2 alone. The improvement is antigen-specific, indicating it blocks PS-dependent immunosuppressive signals, and the immunostimulatory cytokine-IL2 contributes to the vaccination effect observed in research models.
-
What is the target and source of this immunocytokine?
A: This product targets Phosphatidyl Serine (PS) and was achieved by conjugating or fusing the Anti-PS IgG to IL2. It is expressed in CHO cells and purified with affinity chromatography, retaining the ability to bind PS as well as IL2 activity.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "PS"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-819 | Recombinant Anti-PS Antibody | ELISA, WB, Dot, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-819-F(E) | Recombinant Anti-PS Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-819-S(P) | Recombinant Anti-PS Antibody scFv Fragment | ELISA, IF, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-819 | Recombinant Human Anti-PS Antibody | WB, IP, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-819-F(E) | Recombinant Human Anti-PS Antibody Fab Fragment | WB, Dot, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHH-819-S(P) | Recombinant Human Anti-PS Antibody scFv Fragment | WB, Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABZ-170 | Human Anti-PS Recombinant Antibody (clone pSTAb) | ELISA, WB | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABZ-172 | Human Anti-PS Recombinant Antibody (clone pSAb) | ELISA, WB | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABZ-173 | Human Anti-PS Recombinant Antibody (clone pYAb) | ELISA, WB | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBZ-170 | Human Anti-PS Recombinant Antibody (clone pSTAb); Fab Fragment | ELISA, WB | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBZ-172 | Human Anti-PS Recombinant Antibody (clone pSAb); Fab Fragment | ELISA, WB | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBZ-173 | Human Anti-PS Recombinant Antibody (clone pYAb); Fab Fragment | ELISA, WB | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBZ-170 | Human Anti-PS Recombinant Antibody (clone pSTAb); scFv Fragment | ELISA, WB | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBZ-172 | Human Anti-PS Recombinant Antibody (clone pSAb); scFv Fragment | ELISA, WB | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBZ-173 | Human Anti-PS Recombinant Antibody (clone pYAb); scFv Fragment | ELISA, WB | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1082CL | Anti-Human PS Recombinant Antibody (2E5) | ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1083CL | Anti-Human PS Recombinant Antibody (2E7) | ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1082CL-S(P) | Anti-Human PS Recombinant Antibody scFv Fragment (2E5) | ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1083CL-S(P) | Anti-Human PS Recombinant Antibody scFv Fragment (2E7) | ELISA |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1082CL-F(E) | Anti-Human PS Recombinant Antibody Fab Fragment (2E5) | ELISA |
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