Recombinant Human Anti-S. aureus Alpha-hemolysin Antibody (LTM14) (CAT#: PABZ-177)
Recombinant Human Antibody (LTM14) is capable of binding to S. aureus Alpha-hemolysin , expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-S. aureus Alpha-hemolysin mAb and CH1-3 region of human IgG and a light chain (LC) encoding VL from anti-S. aureus Alpha-hemolysin proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. The epitope of LTM14 is centered on α-hemolysin residue R66, which has been implicated in binding to the eukaryotic membrane.
Specific Inquiry
Specifications
- Immunogen
- S. aureus Alpha-hemolysin
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native S. aureus Alpha-hemolysin
- Species Reactivity
- S. aureus
- Clone
- LTM14
- Applications
- ELISA Assay-Dependent
Neut Assay-Dependent
Block Assay-Dependent
FuncS 0.3-30 mg/kg
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- The antibody LTM14 has been reported in applications of ELISA, Neut, Block, FuncS. It's recommended that the optimal antibody concentration, dilution, incubition time etc. are best to be carefully titrated in specific assays.
FuncS: A reported dose of the antibody LTM14 in a mouse model of S. aureus pneumonia.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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ScFv Antibody Products
Fab Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBZ-177 | Recombinant Human Anti-S. aureus Alpha-hemolysin Antibody Fab Fragment (LTM14) | ELISA | Fab |
Customer Reviews and Q&As
Customer Review
Q&As
Enhanced Experimental Flexibility
The availability of various conjugation options has proved beneficial, facilitating its adaptation across diverse assay formats, from ELISAs to functional blocking studies. This flexibility enhances our experimental design possibilities and robustness.
Essential for Pathogen Research
This antibody has become central to our investigations into the role of alpha-hemolysin in S. aureus pathogenicity. Its ability to engage specifically with this virulence factor supports clear insights and accurate data in our research efforts.
Advancing Infection Studies
By using this antibody, our understanding of S. aureus mechanisms in infections has deepened, supporting the development of targeted strategies to mitigate bacterial virulence, which is a crucial focus of our work.
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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