Anti-Human SEMA3A Recombinant Antibody, Humanized

Name: Anti-Human SEMA3A Recombinant Antibody, Humanized
SKU: TAB-556CL
Rating: 5 (1 reviews)

CAT#: TAB-556CL

Recombinant Humanized monoclonal antibody expressed in CHO binding to Human SEMA3A. The anti-Sema3A antibody enables effective prevention and treatment of a disease, in which Sema3A protein participates, such as a neurodegenerative disease, autoimmune disease, inflammatory disease, cancer, infectious disease, etc. or disseminated intravascular coagulation syndrome.

Gene Expression

Subcellular Location and Protein Expression Figure 1 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52235/if_selected.jpg

Subcellular Location and Protein Expression Figure 2 IHC staining of human liver

Immunohistochemical staining of human liver shows cytoplasmic positivity in hepatocytes.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29447/ihc_selected.jpg

Subcellular Location and Protein Expression Figure 3 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52235/816_B11_3_blue_red_green.jpg

Subcellular Location and Protein Expression Figure 4 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/52235/790_B11_1_blue_red_green.jpg

Normal Tissue Figure 5 Cerebral cortex

Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29447/61370_B_7_5.jpg

Normal Tissue Figure 6 Colon

Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29447/61370_A_8_3.jpg

Normal Tissue Figure 7 Liver

Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29447/61370_A_7_4.jpg

Normal Tissue Figure 8 Kidney

Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29447/61370_A_7_5.jpg

Normal Tissue Figure 9 Testis

Cells in seminiferous ducts
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29447/61370_A_4_6.jpg

Normal Tissue Figure 10 Lymph node

Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/29447/61370_A_9_8.jpg

RNA Expression Figure 11 RNA cell line category: Cell line enhanced (AF22, BJ, fHDF/TERT166)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000075213-SEMA3A

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Specifications

Derivation
Humanized

Type
Antibody

Species Reactivity
Human

Related Disease
Neurodegenerative Disease; Autoimmune Disease; Inflammatory Disease; Cancer; Infectious Disease

Product Property

Purity
>90% assessed by SDS-PAGE

Storage
≥1 year at -20°C. If the reconstituted antibody cannot be used within two weeks, it should be aliquoted into smaller vials and stored at -20°C

Target

Alternative Names
SEMA3A; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; HH16; SemD; COLL1; SEMA1; SEMAD; SEMAL; coll-1; Hsema-I; SEMAIII; Hsema-III; semaphorin-3A; collapsin 1; semaphorin D; semaphorin L; semaphorin III

Gene ID
10371

UniProt ID
Q14563

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - TAB-556CL.pdf

MSDS

MSDS - TAB-556CL.pdf

COA

Certificate of Analysis Lookup

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CAT	Product Name	Application	Type
NAB-2258-VHH	Recombinant Anti-Human SEMA3A VHH Single Domain Antibody	IHC, ICC, IP, ChiP, Neut	Llama VHH

CAT	Product Name	Application	Type
MOB-2222z	Mouse Anti-SEMA3A Recombinant Antibody (clone 28B6)	WB, ICC, IHC, IP	Mouse IgG1, κ
HPAB-3172LY	Human Anti-SEMA3A Recombinant Antibody (HPAB-3172LY)	Neut, Inhib	Human IgG
HPAB-3173LY	Human Anti-SEMA3A Recombinant Antibody (HPAB-3173LY)	Neut, Inhib	Human IgG
HPAB-3174LY	Human Anti-SEMA3A Recombinant Antibody (HPAB-3174LY)	FuncS, Neut, Inhib	Human IgG
VS7-0425-WR840	Mouse Anti-SEMA3A Recombinant Antibody (clone 1G6F9)	FC	Mouse IgG1

CAT	Product Name	Application	Type
TAB-421CT	Humanized Anti-SEMA3A Recombinant Antibody (TAB-421CT)	WB, ELISA	Humanized IgG
TAB-421CT-S(P)	Humanized Anti-SEMA3A Recombinant Antibody; scFv Fragment (TAB-421CT-S(P))	WB, ELISA	Humanized scFv
TAB-421CT-F(E)	Humanized Anti-SEMA3A Recombinant Antibody; Fab Fragment (TAB-421CT-F(E))	WB, ELISA	Humanized Fab

CAT	Product Name	Application	Type
NS-078CN	Human Anti-SEMA3A Recombinant Antibody (NS-078CN)	ELISA	Chimeric (avian/human) IgG1
NS-079CN	Human Anti-SEMA3A Recombinant Antibody (NS-079CN)	ELISA	Chimeric (avian/human) IgG1
NS-078CN-F(E)	Human Anti-SEMA3A Recombinant Antibody; Fab Fragment (NS-078CN-F(E))	ELISA	Chimeric (avian/human) Fab
NS-079CN-F(E)	Human Anti-SEMA3A Recombinant Antibody; Fab Fragment (NS-079CN-F(E))	ELISA	Chimeric (avian/human) Fab
NS-078CN-S(P)	Human Anti-SEMA3A Recombinant Antibody; scFv Fragment (NS-078CN-S(P))	ELISA	Human scFv

CAT	Product Name	Application	Type
HPAB-3172LY-S(P)	Human Anti-SEMA3A Recombinant Antibody; scFv Fragment (HPAB-3172LY-S(P))	ELISA, Inhib	Human scfv
HPAB-3173LY-S(P)	Human Anti-SEMA3A Recombinant Antibody; scFv Fragment (HPAB-3173LY-S(P))	ELISA, Inhib	Human scfv
HPAB-3174LY-S(P)	Human Anti-SEMA3A Recombinant Antibody; scFv Fragment (HPAB-3174LY-S(P))	ELISA, Inhib	Human scfv

CAT	Product Name	Application	Type
HPAB-3172LY-F(E)	Human Anti-SEMA3A Recombinant Antibody; Fab Fragment (HPAB-3172LY-F(E))	ELISA, Inhib	Human Fab
HPAB-3173LY-F(E)	Human Anti-SEMA3A Recombinant Antibody; Fab Fragment (HPAB-3173LY-F(E))	ELISA, Inhib	Human Fab
HPAB-3174LY-F(E)	Human Anti-SEMA3A Recombinant Antibody; Fab Fragment (HPAB-3174LY-F(E))	ELISA, Inhib	Human Fab

CAT	Product Name	Application	Type
VS-0625-YC287	Recombinant Anti-SEMA3A Eliminating Antibody, pH-Sensitive (VS-0625-YC287)	Antigen-Sweeping In Vivo.	Human IgG

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