Recombinant Human Anti-VZV gHgL Antibody (Mab94) (CAT#: PABL-744)
Recombinant Human Antibody (Mab94) is capable of binding to VZV gHgL, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-VZV gHgL mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-VZV gHgL proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody has the most VZV-neutralizing activity.
Specific Inquiry
WB
Figure 1 Mutational analyses of the gH/Fab-RC and gHgL/Fab-94 interfaces.
Affinity pull-down using gHgL with mutations in gH (W291A, F292A, W291A/W292A, Loop A mutant) revealed reduced binding to Fab-94.
Xing, Y., Oliver, S. L., Nguyen, T., Ciferri, C., Nandi, A., Hickman, J., ... & Uematsu, Y. (2015). A site of varicella-zoster virus vulnerability identified by structural studies of neutralizing antibodies bound to the glycoprotein complex gHgL. Proceedings of the National Academy of Sciences, 112(19), 6056-6061.
Specifications
- Immunogen
- VZV Glycoproteins gHgL
- Host Species
- Human
- Derivation
- Human
- Type
- IgG
- Specificity
- Tested positive against native VZV gHgL
- Species Reactivity
- VZV
- Clone
- Mab94
- Applications
- WB
Product Property
- Purity
- >95% by SDS-PAGE and HPLC analysis
- Storage
- Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.
Applications
- Application Notes
- This antibody has been reported for use in Western Blot.
Target
- Alternative Names
- gHgL; Glycoproteins gHgL; VZV gHgL
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone Mab94"
See other products for "gHgL"
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-737 | Recombinant Human Anti-VZV gHgL Antibody Fab Fragment (Mab94) | Neut | Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-737 | Recombinant Human Anti-VZV gHgL Antibody scFv Fragment (Mab94) | Neut | scFv |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for PABL-744. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.