Anti-Zinc transporter LIV-1 (hLIV22)-vc-MMAE ADC (SGN-LIV1A ) (CAT#: ADC-L040)

• Antibody Overview
• Humanized IgG1 antibody hLIV22 (Anti-LIV-1)

• Clone
• hLIV22

• Antibody Conjugation
• Humanized

• Linker
• vc (valine-citrulline)

• Linker Class/Description
• Class: Enzymatically cleavable linkers-Peptide linkers
  Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

• Drug
• MMAE (Monomethyl auristatin E)

• Drug Class/Description
• Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

• Introduction
• Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters.

• Alternative Names
• ZIP6; LIV-1

• Gene ID
• 25800

• UniProt ID
• Q13433

• ADC-144LCT
• Anti-LIV-1 (hLIV22)-vc-MMAE ADC

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