BV421-A*02:01/Human PR-1 (VLQELNVTV) MHC Tetramer (CAT#: MHC-LC012)
This product is a tetramer of biotinylated peptide/MHC complex with streptavidin mainly composed of PR-1-derived peptide of VLQELNVTV sequence covering 169-177 and A*02:01 molecule. The pMHC tetramer recognizes human CD8 T cells, and can be used in the analysis of individual antigen-specific T cells.
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MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line Hep G2
(Immunofluorescent staining of human cell line Hep G2 shows localization to nucleoplasm, nucleoli fibrillar center & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53794/if_selected.jpg
(Immunofluorescent staining of human cell line Hep G2 shows localization to nucleoplasm, nucleoli fibrillar center & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53794/if_selected.jpg
Figure 2 Colon
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53794/123928_A_8_3.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53794/123928_A_8_3.jpg
Figure 3 High expression in kidney
(Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53794/123928_A_9_5.jpg
(Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53794/123928_A_9_5.jpg
Figure 4 Testis
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53794/123928_A_6_6.jpg
(Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/53794/123928_A_6_6.jpg
Figure 5 RNA cell line category: Group enriched (EFO-21, Hep G2, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000171227-TMEM37
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000171227-TMEM37
Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- PR-1
- Antigen Species
- Human
- Peptide
- VLQELNVTV
- Range
- 169-177
- Conjugate
- BV421
- Application
- FCM
Target
- Antigen Introduction
- PR1 is a human leukocyte antigen (HLA)-A2 restricted peptide that has been targeted successfully in myeloid leukemia with immunotherapy. PR1 is derived from the neutrophil granule proteases proteinase 3 (P3) and neutrophil elastase (NE), which are both found in the tumor microenvironment.
- Alternative Names
- TMEM37; transmembrane protein 37; PR; PR1
- Gene ID
- 140738
- UniProt ID
- Q8WXS4
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MHC Tetramer Products for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC010 | PE-A*02:01/Human PR-1 (VLQELNVTV) MHC Tetramer | FCM | |
| MHC-LC011 | APC-A*02:01/Human PR-1 (VLQELNVTV) MHC Tetramer | FCM | |
| MHC-CN0329 | APC-A*02:01/Human PR1 (VLQELNVTV) MHC Tetramer | FCM | |
| MHC-CN0330 | PE-A*02:01/Human PR1 (VLQELNVTV) MHC Tetramer | FCM | |
| MHC-YF229 | A*02:01/Human PR-1 (VLQELNVTV) MHC Monomer | MHC Multimer |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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