Recombinant Anti-CD18 × Anti-C3d Bispecific Antibody (IgG-IgG)

Name: Recombinant Anti-CD18 × Anti-C3d Bispecific Antibody (IgG-IgG)
SKU: BSIG-L001
Rating: 5 (1 reviews)

CAT#: BSIG-L001

Anti-CD18 × Anti-C3d Bispecific Antibody (IgG-IgG) is a chemical conjugate composed of the anti-CD18 monoclonal antibody and the other antibody specific for C3d. A stable thioether linkage is formed between the two antibodies. This BsAb can reverse the consequences of opsonin-receptor mismatch by permitting interactions between PMN phagocytosis receptors and C3b or a bacteria antigen, thereby enhancing the phagocytosis and killing of bacteria. It was designed for the treatment of bacterial infection in the lungs of cystic fibrosis (CF).

Specifications

Target
CD18 & C3d

Type
IgG-IgG

Species Reactivity
Human

Target 1
CD18

Host Species 1
Mouse

Target 2
C3d

Host Species 2
Pseudomonas aeruginosa

Application
FuncS, Promising therapeutic agent

Related Disease
Cystic fibrosis (CF)

Target

Target 1
CD18

Gene ID
3689

UniProt ID
P05107

Alternative Names
ITGB2; integrin, beta 2; complement component 3 receptor 3 and 4 subunit; LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1

Target 2
C3d

Gene ID
718

UniProt ID
P01024

Alternative Names
ASP; C3a; C3b; AHUS5; ARMD9; CPAMD1; HEL-S-62p

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Datasheet

Datasheet - BSIG-L001.pdf

MSDS

MSDS - BSIG-L001.pdf

COA

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