Recombinant Anti-CD22 × Anti-CD79B Bispecific Antibody (Tandem Diabody)

CAT#: TAND-LC001

The anti-CD22/CD79b antibody specifically binds to both CD22 and CD79b, and the antibody can be potentially used in the treatment of autoimmune diseases, such as SLE.

Specifications

  • Target
  • CD22 & CD79b
  • Type
  • Tandem Diabody
  • Species Reactivity
  • Human
  • Target 1
  • CD22
  • Host Species 1
  • Rabbit
  • Target 2
  • CD79b
  • Host Species 2
  • Rabbit
  • Application
  • FC
  • Related Disease
  • Autoimmune disease

Target

  • Target 1
  • CD22
  • Alternative Names
  • CD22; CD22 molecule; SIGLEC2; SIGLEC-2; B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2
  • Target 2
  • CD79b
  • Alternative Names
  • CD79B; CD79b molecule, immunoglobulin-associated beta; B29; IGB; AGM6; B-cell antigen receptor complex-associated protein beta chain; Ig-beta; B-cell-specific glycoprotein B29; immunoglobulin-associated B29 protein; CD79b antigen (immunoglobulin-associated beta)
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Breast cancer biomarkers at key points during disease progression
Great For Internalization Studies
We are investigating antibody internalization rates for ADC development, and this bispecific targeting CD22 and CD79B showed rapid internalization in B cell lymphoma lines. The dual targeting strategy seems to enhance uptake compared to single antigen targeting.
Breast cancer biomarkers at key points during disease progression
High Specificity For B Cells
The antibody is highly specific for B cell lineages. We tested it on a panel of different cell lines, and it only bound to those expressing both CD22 and CD79B, which gives us confidence in using it for targeted delivery research.

Q&As

  1. Is this antibody suitable for Antibody-Drug Conjugate (ADC) research?

    A: Yes, this bispecific antibody targeting CD22 and CD79B is highly suitable for ADC research. Both targets are known to internalize upon antibody binding. By targeting both simultaneously, you can potentially enhance the internalization rate and lysosomal delivery of cytotoxic payloads in B cell malignancies.

  2. What specific cell types does this antibody target?

    A: This antibody is designed to target B cell lineages, specifically those expressing CD22 and CD79B. These antigens are commonly found on B cell lymphomas and leukemias, making this product a valuable tool for researching targeted therapies for B cell-derived hematological cancers.

View the frequently asked questions answered by Creative Biolabs Support.

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