Recombinant Anti-EGFR × Anti-HER3 Bispecific Antibody (Tandem Diabody)
CAT#: TAND-L032
Recombinant Anti-EGFR × Anti-HER3 Bispecific Antibody (Tandem Diabody) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. Tandem Diabodies do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than tandem scFvs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with tandem scFvs. This BsAb is capable of blocking EGFR as well as HER3 simultaneously. BsAb-mediated simultaneous interference with two (or more) RTK signaling pathways, by inactivating either the RTKs or their ligand, should reduce the possibility of such escape mechanisms and, hence, improve therapeutic efficacy. It was designed for the treatment of Hodgkin's lymphoma.
Specifications
- Target
- EGFR & HER3
- Type
- Tandem Diabody
- Species Reactivity
- Human
- Target 1
- EGFR
- Host Species 1
- Rabbit
- Target 2
- HER3
- Host Species 2
- Rabbit
- Application
- FuncS, Promising therapeutic agent
- Related Disease
- Hodgkin's Lymphoma
Target
- Target 1
- EGFR
- Gene ID
- 1956
- UniProt ID
- P00533
- Alternative Names
- EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1;
- Target 2
- HER3
- Gene ID
- 2065
- UniProt ID
- P21860
- Alternative Names
- ERBB3; erb-b2 receptor tyrosine kinase 3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; human epidermal growth factor receptor 3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| CROSS-L013 | Recombinant Anti-EGFR × Anti-HER3 Bispecific Antibody (CrossMab) | FuncS, Promising therapeutic agent | CrossMab |
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