EGFR & HER3

Anti-EGFR & HER3 Products

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Anti-Human EGFR Recombinant Antibody (Cetuximab) (TAB-003)
- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
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Anti-EGFR Antibody-Cytokine Fusion Protein, IL2-IgG (mAb 425) (ACFP-SH078)
- Target: EGFR
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Mouse
- Cytokine 1 Species: Human
- Molecule Class: IL2-IgG2a
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Mouse Anti-EGFR Recombinant Antibody (clone 7A7) (PABW-088)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, WB
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Anti-EGFR Recombinant Antibody (Imgatuzumab) (TAB-753)
- Derivation: Humanized (from rat)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: Neut, ELISA, IF, IP, FuncS, FC, WB
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Anti-Human EGFR Recombinant Antibody (Modotuximab) (TAB-H49)
- Derivation: Chimeric
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
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Anti-Human EGFR Recombinant Antibody (Panitumumab) (TAB-020)
- Derivation: Human
- Species Reactivity: Human
- Type: IgG2 - kappa
- Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
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Anti-EGFR Recombinant Antibody (Nimotuzumab) (TAB-710)
- Derivation: Humanized (from mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: ELISA, IP, FC, FuncS, Neut, IF, IHC
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Anti-Human EGFR Recombinant Antibody (TAB-119) (TAB-119)
- Derivation: Human
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: FC, IP, ELISA, Neut, FuncS, IF, WB
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Anti-Human EGFR Recombinant Antibody (ABT-806) (TAB-228CL)
- Derivation: Humanized
- Species Reactivity: Human
- Type: Antibody
- Application: WB, IHC
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Mouse Anti-EGFR Recombinant Antibody (TAB-271MZ) (TAB-271MZ)
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: FuncS
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Human Anti-EGFR Recombinant Antibody (TAB-272MZ) (TAB-272MZ)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG
- Application: FuncS
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Mouse Anti-EGFR Recombinant Antibody (PABW-171) (PABW-171)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB
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Human Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-270MZ-S(P)) (TAB-270MZ-S(P))
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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Human Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-274MZ-S(P)) (TAB-274MZ-S(P))
- Species Reactivity: Human
- Type: Humanized scFv
- Application: FC
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Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-272MZ-S(P)) (TAB-272MZ-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: FuncS
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Human Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-270MZ-F(E)) (TAB-270MZ-F(E))
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA
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Human Anti-EGFR Recombinant Antibody (TAB-274MZ) (TAB-274MZ)
- Species Reactivity: Human
- Type: Humanized IgG
- Application: FC
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Human Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-272MZ-F(E)) (TAB-272MZ-F(E))
- Species Reactivity: Human
- Type: Chimeric (mouse/human) Fab
- Application: FuncS
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Human Anti-EGFR Recombinant Antibody (TAB-278MZ) (TAB-278MZ)
- Species Reactivity: Human
- Type: Human IgG
- Application: Cyt, ELISA, Inhib
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Human Anti-EGFR Recombinant Antibody (TAB-279MZ) (TAB-279MZ)
- Species Reactivity: Human
- Type: Human IgG
- Application: Cyt, ELISA, Inhib
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Anti-EGFR/HER1 Recombinant Antibody (TAB-750) (TAB-750)
- Derivation: Chimeric (Human/Mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: Neut, ELISA, IF, IP, FuncS, FC, WB
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Mouse Anti-EGFR Recombinant Antibody (clone 42C11) (MOB-1078z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, FC, IF, IHC, FuncS
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Anti-Human EGFR Recombinant Antibody (Futuximab) (TAB-H35)
- Derivation: Chimeric (human/mouse)
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: IF, WB, Inhib
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Anti-Human EGFR Recombinant Antibody (Matuzumab) (TAB-165)
- Derivation: Humanized
- Species Reactivity: Human
- Type: IgG1
- Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
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Afuco™ Anti-Human EGFR ADCC Recombinant Antibody (ABT-806), ADCC Enhanced (AFC-216CL)
- Derivation: Humanized
- Species Reactivity: Human
- Type: ADCC enhanced antibody
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Anti-Human EGFR Recombinant Antibody (TAB-040) (TAB-040)
- Derivation: Human
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
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Human Anti-EGFR Recombinant Antibody (PABL-080) (PABL-080)
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, WB, FuncS
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Human Anti-EGFR Recombinant Antibody (clone C225) (PABL-462)
- Species Reactivity: Human
- Type: Human IgG
- Application: FC
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Human Anti-EGFR Recombinant Antibody (PABL-463) (PABL-463)
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA, WB, FuncS
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Mouse Anti-EGFR Recombinant Antibody (clone 7A7); Fab Fragment (PFBW-088)
- Species Reactivity: Human
- Type: Mouse Fab
- Application: ELISA, WB
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Mouse Anti-EGFR Recombinant Antibody (clone 7A7); scFv Fragment (PSBW-088)
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, WB
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Human Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-0225CL-S(P)) (TAB-0225CL-S(P))
- Species Reactivity: Human
- Type: Human scFv
- Application: Block, Inhib, FuncS, Apop, In vivo
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Human Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-0225CL-F(E)) (TAB-0225CL-F(E))
- Derivation: Chimeric (Mouse/Human)
- Species Reactivity: Human
- Type: Chimeric (Mouse/Human) Fab
- Application: Block, Inhib, FuncS, Apop, In vivo
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Human Anti-EGFR Recombinant Antibody (TAB-287MZ) (TAB-287MZ)
- Species Reactivity: Human
- Type: Human IgG1
- Application: ADCC assay
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Human Anti-EGFR Recombinant Antibody (TAB-288MZ) (TAB-288MZ)
- Species Reactivity: Human
- Type: Human IgG1
- Application: ADCC assay
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Human Anti-EGFR Recombinant Antibody (TAB-289MZ) (TAB-289MZ)
- Species Reactivity: Human
- Type: Human IgG1
- Application: ADCC assay
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Human Anti-EGFR Recombinant Antibody (TAB-290MZ) (TAB-290MZ)
- Species Reactivity: Human
- Type: Human IgG
- Application: Block, Cyt, ELISA, FC, FuncS, Inhib
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Human Anti-EGFR Recombinant Antibody (TAB-291MZ) (TAB-291MZ)
- Species Reactivity: Human
- Type: Human IgG
- Application: Block, Cyt, ELISA, FC, FuncS, Inhib
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Human Anti-EGFR Recombinant Antibody (TAB-292MZ) (TAB-292MZ)
- Species Reactivity: Human
- Type: Human IgG
- Application: In vitro binding assay
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Human Anti-EGFR Recombinant Antibody (TAB-293MZ) (TAB-293MZ)
- Species Reactivity: Human
- Type: Human IgG
- Application: In vitro binding assay
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Human Anti-EGFR Recombinant Antibody (TAB-282MZ) (TAB-282MZ)
- Species Reactivity: Human
- Type: Human IgG
- Application: Cyt, FuncS, Inhib
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Human Anti-EGFR Recombinant Antibody (TAB-283MZ) (TAB-283MZ)
- Species Reactivity: Human
- Type: Human IgG
- Application: Cyt, FuncS, Inhib
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Human Anti-EGFR Recombinant Antibody (TAB-284MZ) (TAB-284MZ)
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA
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Rabbit Anti-Human EGFR (phospho Y1092) Antibody (MOB-0242MC)
- Species Reactivity: Rat, Human
- Application: IHC, WB
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Rabbit Anti-Human EGFR (phospho Y1068) Antibody (MOB-0243MC)
- Species Reactivity: Human, Mouse, Rat
- Application: IHC, WB
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Mouse Anti-EGFR Recombinant Antibody (clone mAb528) (PABZ-039)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC
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Human Anti-EGFR Recombinant Antibody (PABW-039) (PABW-039)
- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG
- Application: FuncS
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Human Anti-EGFR Recombinant Antibody (clone MR1) (PABC-040)
- Species Reactivity: Human
- Type: Human IgG
- Application: Block
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Mouse Anti-EGFR Recombinant Antibody (clone mAb528); Fab Fragment (PFBZ-039)
- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC
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Mouse Anti-EGFR Recombinant Antibody (TAB-285MZ) (TAB-285MZ)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: FuncS
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Mouse Anti-EGFR Recombinant Antibody (TAB-286MZ) (TAB-286MZ)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: FuncS
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Mouse Anti-EGFR Recombinant Antibody (clone mAb528); scFv Fragment (PSBZ-039)
- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC
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Recombinant Anti-Human EGFR VHH Single Domain Antibody (PNBL-016) (PNBL-016)
- Derivation: Llama
- Species Reactivity: Human
- Type: Llama VHH
- Application: WB, ELISA
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Recombinant Anti-Human EGFR VHH Single Domain Antibody (PNBL-017) (PNBL-017)
- Derivation: Llama
- Species Reactivity: Human
- Type: Llama VHH
- Application: FuncS, ELISA, IF
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Recombinant Anti-Human EGFR VHH Single Domain Antibody (PNBL-018) (PNBL-018)
- Derivation: Llama
- Species Reactivity: Human
- Type: Llama VHH
- Application: FuncS, SPR
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10-FnIII scaffold protein anti-Human EGFR (SFN-L003)
- Scaffold Name: 10-FnIII
- Target: EGFR
- Species Reactivity: Human
- Derivation: Phage display
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Z-domain of protein A scaffold protein anti-Human EGFR (SZA-L219)
- Scaffold Name: Z-domain of protein A
- Target: EGFR
- Species Reactivity: Human
- Derivation: Phage display
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Recombinant Anti-Mouse Egfr VHH Single Domain Antibody (NABG-056)
- Species Reactivity: Mouse
- Type: Llama VHH
- Application: ELISA, IHC, FC, FuncS
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Mouse Anti-EGFR Recombinant Antibody (TAB-281MZ) (TAB-281MZ)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IF, IHC
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Mouse Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-273MZ-F(E)) (TAB-273MZ-F(E))
- Species Reactivity: Human
- Type: Mouse Fab
- Application: FC
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Mouse Anti-EGFR Recombinant Antibody (TAB-273MZ) (TAB-273MZ)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: FC, FuncS, IHC, IP, Inhib
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Mouse Anti-EGFR Recombinant Antibody (TAB-275MZ) (TAB-275MZ)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: Cyt, FuncS, Inhib
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Anti-Human EGFR Recombinant Antibody (LA1) (TAB-276MZ)
- Application: Cyt, FuncS
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Anti-Human EGFR Recombinant Antibody (LA22) (TAB-277MZ)
- Application: Cyt, FuncS
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Mouse Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-271MZ-F(E)) (TAB-271MZ-F(E))
- Species Reactivity: Human
- Type: Mouse Fab
- Application: FuncS
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Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-273MZ-S(P)) (TAB-273MZ-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC
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Anti-EGFR Antibody-Cytokine Fusion Protein, IgG (Ch225)-IL2 (ACFP-SH079)
- Target: EGFR
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Chimeric (Mouse-Human)
- Cytokine 1 Species: Human
- Molecule Class: IgG-IL2
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Anti-EGFR Antibody-Cytokine Fusion Protein, TNF-IgG (mAb 425) (ACFP-SH080)
- Target: EGFR
- Species Reactivity: Human
- Cytokine 1: TNFα
- Host: Mouse
- Cytokine 1 Species: Human
- Molecule Class: TNF-IgG2a
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Human Anti-EGFR Recombinant Antibody; scFv Fragment (PSBL-080) (PSBL-080)
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, WB, FuncS
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Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-275MZ-S(P)) (TAB-275MZ-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: FC
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Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-271MZ-S(P)) (TAB-271MZ-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: FuncS
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Anti-EGFR Antibody-Cytokine Fusion Protein, IgG-IL2 (ACFP-SH155)
- Target: EGFR
- Species Reactivity: Human
- Cytokine 1: IL2
- Host: Humanized from Mouse
- Cytokine 1 Species: Human
- Molecule Class: IgG1-IL2
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Human Anti-EGFR Recombinant Antibody (clone C225); scFv Fragment (PSBL-459)
- Species Reactivity: Human
- Type: Human scFv
- Application: FC
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Human Anti-EGFR Recombinant Antibody (clone h-R3); scFv Fragment (PSBL-460)
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, WB, FuncS
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Human Anti-EGFR Recombinant Antibody (clone C225); Fab Fragment (PFBL-459)
- Species Reactivity: Human
- Type: Human Fab
- Application: FC
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Human Anti-EGFR Recombinant Antibody (clone h-R3); Fab Fragment (PFBL-460)
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, WB, FuncS
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Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-0564CL-S(P)) (TAB-0564CL-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-0565CL-S(P)) (TAB-0565CL-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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Anti-EGFR (ABT-806)-Mc-MMAE ADC (ABT-414) (ADC-L001)
- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-EGFR (J2898A)-SMCC-DM1 ADC (IMGN289) (ADC-L016)
- Target: EGFR
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto- 1-oxopropyl)maytansine)
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Anti-EGFR (clone Antibody 1)-MC-MMAF ADC (ADC-059CL)
- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-EGFR-doxorubicin ADC (ADC-168LZY)
- Target: EGFR
- Linker: polyethylene glycol linker
- Drug: doxorubicin
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Recombinant Anti-EGFR × Anti-HER3 Bispecific Antibody (CrossMab) (CROSS-L013)
- Targets: EGFR & HER3
- Type: CrossMab
- Application: FuncS, Promising therapeutic agent
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Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-037CL)
- Target: EGFR
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
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Anti-EGFR-MC-VC-PABA-MMAE ADC (ADC-038CL)
- Target: EGFR
- Linker: MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
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Anti-EGFR (clone Bat0206)-S-3AA-MDC ADC (ADC-157CL)
- Target: EGFR
- Linker: S-3AA
- Drug: MDC (maytansinol)
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Anti-EGFR-mc-MMAF ADC (ADC-039CL)
- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-EGFR-vc-PAB-MODO ADC (ADC-263CL)
- Target: epidermal growth factor receptor (EGFR)
- Linker: VC-PAB (valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MODO (monomethyldolastatin)
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Anti-EGFR-Mal-dPEG4-NHS-DM1 ADC (ADC-107LCT)
- Target: EGFR
- Linker: Mal-dPEG4-NHS
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-EGFR (clone J2898A)-SMCC-DM1 ADC (ADC-047LZY)
- Target: EGFR
- Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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Anti-EGFR (MAb806)-Mc-MMAF ADC (ADC-109LCT)
- Target: EGFR
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-EGFRvIII-SMCC-DM1 ADC (ADC-048LZY)
- Target: EGFRvIII
- Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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Anti-EGFR (MAb806)-SMCC-DM1 ADC (ADC-110LCT)
- Target: EGFR variant III
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
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Anti-EGFR-MCC-Dox ADC (ADC-057LZY)
- Target: EGFR
- Linker: MCC (4-(N-maleimidomethyl)cyclohexane-1-carboxylate)
- Drug: doxorubicin
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Anti-EGFR-EDC/NHS-Dox ADC (ADC-058LZY)
- Target: EGFR
- Linker: EDC/NHS(1-ethyl-3-(3-diaminopropyl)carbodiimide/N-hydroxysuccinimide)
- Drug: doxorubicin
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Anti-EGFR (clone Bat0206)-SMCC-MDC ADC (ADC-158CL)
- Target: EGFR
- Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
- Drug: MDC (maytansinol)
Compare

Anti-EGFR-SMCC-methotrexate ADC (ADC-059LZY)
- Target: EGFR
- Linker: SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
- Drug: MTX
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Anti-EGFR-EDC/NHS-methotrexate ADC (ADC-060LZY)
- Target: EGFR
- Linker: EDC/NHS
- Drug: MTX
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Anti-EGFR (clone ABT-806)-mc-MMAF ADC (ADC-071LZY)
- Target: EGFR
- Linker: mc (maleimidocaproyl)
- Drug: MMAF (monomethyl auristatin F)
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Anti-EGFR-vc-Duostatin-3 ADC (ADC-088LZY)
- Target: EGFR
- Linker: VC (valine-citrulline)
- Drug: Duostatin-3
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For Research Use Only. Not For Clinical Use.

Background

Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin. Isoform 2 may act as an antagonist of EGF action.

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Related Signaling Pathways

JAK-STAT Signaling Pathway