Recombinant Anti-FIXa × Anti-FX Bispecific Antibody (CrossMab)
CAT#: CROSS-L011
Recombinant Anti-FIXa × Anti-FX Bispecific Antibody (CrossMab) has been generated by applying the Crossmab format to generate an IgGshaped entity that binds each ligand with one arm. The cognate antigens that are bound by this bispecific antibody are Factor IXa and Factor X in the coagulation cascade. In healthy subjects, these factors are brought together by coagulation factor VIIIa, which is missing in the bleeding disorder hemophilia A. It was designed for the treatment of bleeding disorder hemophilia A.
Specifications
- Target
- FIXa & FX
- Type
- CrossMab
- Species Reactivity
- Human
- Target 1
- FIXa
- Host Species 1
- Human
- Target 2
- FX
- Host Species 2
- Human
- Application
- FuncS, Promising therapeutic agent
- Related Disease
- Bleeding disorder hemophilia A
Target
- Target 1
- FIXa
- Gene ID
- 2158
- UniProt ID
- P00740
- Alternative Names
- F9; coagulation factor IX; FIX; P19; PTC; HEMB; THPH8; F9 p22; FIX F9; factor 9; factor IX F9; Christmas factor; plasma thromboplastic component; plasma thromboplastin component
- Target 2
- FX
- Gene ID
- 2159
- UniProt ID
- P00742
- Alternative Names
- F10; coagulation factor X; FX; FXA; factor Xa; prothrombinase; Stuart-Prower factor
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