Recombinant Anti-FOLR1 × Anti-CD3 Bispecific Antibody (Tandem Diabody)
CAT#: TAND-L059
Recombinant Anti-FBP × Anti-CD3 Bispecific Antibody (Tandem Diabody) is a bispecific fusion protein with four binding sites, two of which bind to tumor cell surface antigens and the other two to the immune cells. Tandem Diabodies do not carry Fc domains. So they are smaller than whole IgGs or IgG-derived BsAbs but larger than tandem scFvs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with tandem scFvs. This BsAb is capable of targeting the tumor and recruiting T effector cells via binding to the CD3 subunit of the T cell receptor complex. It was designed for the treatment of ovarian cancer.
Specifications
- Target
- FOLR1 & CD3
- Type
- Tandem Diabody
- Species Reactivity
- Human
- Target 1
- FOLR1
- Host Species 1
- Mouse
- Target 2
- CD3
- Host Species 2
- Mouse
- Application
- FuncS, Promising therapeutic agent
- Related Disease
- Ovarian cancer
Target
- Target 1
- FOLR1
- Gene ID
- 2348
- UniProt ID
- P15328
- Alternative Names
- FOLR1; folate receptor 1 (adult); FBP; FOLR; folate receptor alpha; FR-alpha; KB cells FBP; folate binding protein; folate receptor, adult; adult folate-binding protein; ovarian tumor-associated antigen MOv18
- Target 2
- CD3
- Gene ID
- 916
- UniProt ID
- P07766
- Alternative Names
- CD3E; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAB-L067 | Recombinant Anti-FOLR1 × Anti-CD3 Bispecific Antibody (Fab2) | FuncS, Promising therapeutic agent | Fab2 |
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