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FOLR1 & CD3

The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene.
In immunology, the CD3 (cluster of differentiation 3) T-cell co-receptor is a protein complex and is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with a molecule known as the T-cell receptor (TCR) and the ζ-chain to generate an activation signal in T lymphocytes. The TCR, ζ-chain, and CD3 molecules together comprise the TCR complex.
  • Anti-FR-S-S-Dox ADC (ADC-170LZY)
    • Target: folate receptor (FR)
    • Linker: disulfide ("S-S") linker
    • Drug: doxorubicin
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    • Target: FRα
    • Linker: maleimide containing linkers
    • Drug: DGN462
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    • Target: FRα
    • Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
    • Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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  • TRX4 (Gly-002CL)
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