Recombinant Anti-HER2 × Anti-CD3 Bispecific Antibody (CrossMab)
CAT#: CROSS-L026
Recombinant Anti-HER2 × Anti-CD3 Bispecific Antibody (CrossMab) has been generated by applying the Crossmab format to generate an IgG shaped entity that binds each ligand with one arm. This BsAb is capable of targeting the tumor and recruiting T effector cells via binding to the CD3 subunit of the T cell receptor complex. It was designed for the treatment of Prostate cancer.
Specifications
- Target
- HER2 & CD3
- Type
- CrossMab
- Species Reactivity
- Human
- Target 1
- HER2
- Host Species 1
- Mouse
- Target 2
- CD3
- Host Species 2
- Mouse
- Application
- FuncS, Promising therapeutic agent
- Related Disease
- Prostate cancer
Target
- Target 1
- HER2
- Gene ID
- 2064
- UniProt ID
- P04626
- Alternative Names
- ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 1
- Target 2
- CD3
- Gene ID
- 916
- UniProt ID
- P07766
- Alternative Names
- CD3E; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
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Effective For Solid Tumors
We applied this bispecific antibody in our solid tumor co-culture models targeting HER2. It successfully induced T cell infiltration and killing of the cancer cells, providing us with valuable data on immune synapse formation in a solid tumor context.
Specific Binding Properties
The specificity for HER2 high-expressing cells was confirmed in our binding assays. It did not show non-specific binding to HER2 negative controls, which makes it a precise tool for studying redirected T cell immunotherapy strategies in breast cancer research.
Q&As
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Can this product be used to study immune responses in solid tumors?
A: Absolutely. This bispecific antibody is designed to target HER2, a common marker in solid tumors like breast and gastric cancer, and CD3 on T cells. It is an excellent tool for researchers investigating T cell infiltration, activation, and tumor cell lysis in the context of HER2-positive solid malignancies.
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What technology is used to produce this HER2 and CD3 bispecific antibody?
A: We produce this antibody using the CrossMab format. This advanced engineering technique enforces the correct assembly of the light and heavy chains from two different antibodies, ensuring that the final product is a functional bispecific molecule that binds specifically to both HER2 and CD3.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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See other products for "HER2 & CD3"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAB-L053 | Recombinant Anti-HER2 × Anti-CD3 Bispecific Antibody (Fab2) | FuncS, Promising therapeutic agent | Fab2 |
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