Recombinant Anti-HER2 × Anti-CD3 Bispecific Antibody (Fab2)
CAT#: FAB-L053
Recombinant Anti-HER2 × Anti-CD3 Bispecific Antibody (Fab2) is composed of the Fab of the anti-HER2 monoclonal antibody and Fab of an antibody specific for CD3. A linker is added between the two Fab. The bispecific antibody is somewhat smaller than a whole IgG, and therefore it clears from the blood naturally at a faster rate. This BsAb is capable of targeting the tumor and recruiting T effector cells via binding to the CD3 subunit of the T cell receptor complex. It was designed for the treatment of ovarian and breast carcinomas.
Specifications
- Target
- HER2 & CD3
- Type
- Fab2
- Species Reactivity
- Human
- Target 1
- HER2
- Host Species 1
- Mouse
- Target 2
- CD3
- Host Species 2
- Mouse
- Application
- FuncS, Promising therapeutic agent
- Related Disease
- Ovarian and breast carcinomas
Target
- Target 1
- HER2
- Gene ID
- 2064
- UniProt ID
- P04626
- Alternative Names
- ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 1
- Target 2
- CD3
- Gene ID
- 916
- UniProt ID
- P07766
- Alternative Names
- CD3E; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell antigen receptor complex, epsilon subunit of T3
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| CROSS-L026 | Recombinant Anti-HER2 × Anti-CD3 Bispecific Antibody (CrossMab) | FuncS, Promising therapeutic agent | CrossMab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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