Recombinant Anti-PDGFR2 × Anti-VEGFR2 Bispecific Antibody (Tandem Diabody)
CAT#: TAND-L048
Recombinant Anti-PDGFR2 × Anti-VEGFR2 Bispecific Antibody (Tandem Diabody) is a bispecific fusion protein with four binding sites, two of which bind to antigens of one kind of cells and the other two to the other kind of cells. Tandem Diabodies do not carry Fc domains, are smaller than whole IgGs or IgG-derived BsAbs, but larger than tandem scFvs. Therefore, they have a shorter serum half-life than IgGs but remain longer in the circulation compared with tandem scFvs. This BsAb can block 2 receptors. It was designed for the treatment of various tumors.
Specifications
- Target
- PDGFR2 & VEGFR2
- Type
- Tandem Diabody
- Species Reactivity
- Mouse
- Target 1
- PDGFR2
- Host Species 1
- Human
- Target 2
- VEGFR2
- Host Species 2
- Human
- Application
- FuncS, Promising therapeutic agent
- Related Disease
- Various tumors
Target
- Target 1
- PDGFR2
- Gene ID
- 18595
- UniProt ID
- P26618
- Alternative Names
- PDGFRA; platelet derived growth factor receptor, alpha polypeptide; CD140a; Pdgfr-2; AI115593; platelet-derived growth factor receptor alpha; PDGFR-alpha; PDGF-R-alpha; PDGF alpha chain; CD140 antigen-like family member A; platelet-derived growth factor a
- Target 2
- VEGFR2
- Gene ID
- 16542
- UniProt ID
- Q8VCD0
- Alternative Names
- KDR; kinase insert domain protein receptor; Flk1; Ly73; Flk-1; Krd-1; VEGFR2; VEGFR-2; sVEGFR-2; 6130401C07; vascular endothelial growth factor receptor 2; kinase NYK; VEGF receptor-2; fetal liver kinase 1; protein-tyrosine kinase receptor flk-1; vascular endothelial growth factor receptor-2; vascular endothelial growth factor receptor-3; vascular endothelial growth factor receptor- 2; soluble vascular endothelial growth factor receptor 2
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